Plasma Levels of Protein S, Protein C, and Factor X: Effects of Sex, Hormonal State and Age

C M A Henkens; V J J Bom; W van der Schaaf; P M Pelsma; C Th Smit Sibinga; P J de Kam; J van der Meer

doi:10.1055/s-0038-1649925

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1995; 74(05): 1271-1275
DOI: 10.1055/s-0038-1649925

Original Article

Coagulation

Schattauer GmbH Stuttgart

Plasma Levels of Protein S, Protein C, and Factor X: Effects of Sex, Hormonal State and Age

C M A Henkens

¹The Department of Haematology, Division of Haemostasis, Thrombosis and Rheology, University Hospital, Groningen, The Netherlands

,

V J J Bom

¹The Department of Haematology, Division of Haemostasis, Thrombosis and Rheology, University Hospital, Groningen, The Netherlands

,

W van der Schaaf

¹The Department of Haematology, Division of Haemostasis, Thrombosis and Rheology, University Hospital, Groningen, The Netherlands

,

P M Pelsma

¹The Department of Haematology, Division of Haemostasis, Thrombosis and Rheology, University Hospital, Groningen, The Netherlands

,

C Th Smit Sibinga

²The Red Cross Bloodbank, Gronlngen-Drenthe, Groningen, The Netherlands

,

P J de Kam

³The Trial Coordination Centre, University Hospital, Groningen, The Netherlands

,

J van der Meer

¹The Department of Haematology, Division of Haemostasis, Thrombosis and Rheology, University Hospital, Groningen, The Netherlands

› Institutsangaben

Abstract

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Summary

We measured total and free protein S (PS), protein C (PC) and factor X (FX) in 393 healthy blood donors to assess differences in relation to sex, hormonal state and age. All measured proteins were lower in women as compared to men, as were levels in premenopausal women as compared to postmenopausal women. Multiple regression analysis showed that both age and subgroup (men, pre- and postmenopausal women) were of significance for the levels of total and free PS and PC, the subgroup effect being caused by the differences between the premenopausal women and the other groups. This indicates a role of sex-hormones, most likely estrogens, in the regulation of levels of pro- and anticoagulant factors under physiologic conditions. These differences should be taken into account in daily clinical practice and may necessitate different normal ranges for men, pre- and postmenopausal women.

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Referenzen

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