Impaired Fibrinolytic Capacity Predisposes for Recurrence of Venous Thrombosis

C Korninger; K Lechner; H Niessner; H Gössinger; M Kundi

doi:10.1055/s-0038-1661155

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1984; 52(02): 127-130
DOI: 10.1055/s-0038-1661155

Original Article

Schattauer GmbH Stuttgart

Impaired Fibrinolytic Capacity Predisposes for Recurrence of Venous Thrombosis

Authors

C Korninger

¹The 1st Department of Medicine1 (Head: Prof. Dr. Dr. h. c. E. Deutsch) Division of Haematology and Blood Coagulation, University of Vienna, Austria
K Lechner

¹The 1st Department of Medicine1 (Head: Prof. Dr. Dr. h. c. E. Deutsch) Division of Haematology and Blood Coagulation, University of Vienna, Austria
H Niessner

¹The 1st Department of Medicine1 (Head: Prof. Dr. Dr. h. c. E. Deutsch) Division of Haematology and Blood Coagulation, University of Vienna, Austria
H Gössinger

¹The 1st Department of Medicine1 (Head: Prof. Dr. Dr. h. c. E. Deutsch) Division of Haematology and Blood Coagulation, University of Vienna, Austria
M Kundi

²The Department of Environmental Hygiene, University of Vienna, Austria

Abstract

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Summary

The fibrinolytic capacity of 121 patients with a history of venous thrombosis and/or pulmonary embolism was studied by venous occlusion technique, at earliest 3 months after the last thromboembolic episode. After discontinuation of oral anticoagulation treatment the clinical course of the patients was followed and new thromboembolic episodes were noted. During the observation period of 56 ± 18.8 months 45 of 121 patients experienced recurrence of thrombosis. The recurrence-rate was significantly lower in patients with a post-occlusion ELT shorter than 60 min (4.8%/year) than in patients with an ELT longer than 60 min (10.3%/year). It is concluded that the fibrinolytic capacity is a useful parameter for determining the risk of recurrence in patients with venous thrombosis.

Keywords

Tissue-type plasminogen activator - Fibrinolytic capacity-venous thrombosis - Recurrence

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References

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