Evaluation of the Cuticle Bleeding Time in Canine Haemophilia A

M I M Pijnappels; E Briët; G Th van der Zwet; R Huisden; N H van Tilburg; F Eulderink

doi:10.1055/s-0038-1661450

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1986; 55(01): 070-073
DOI: 10.1055/s-0038-1661450

Original Article

Schattauer GmbH Stuttgart

Evaluation of the Cuticle Bleeding Time in Canine Haemophilia A

Authors

M I M Pijnappels

The Haemostasis and Thrombosis Research Unit, University Hospital, Leiden, The Netherlands
E Briët

The Haemostasis and Thrombosis Research Unit, University Hospital, Leiden, The Netherlands
G Th van der Zwet

¹The Department of Physiology, University Hospital, Leiden, The Netherlands
R Huisden

The Haemostasis and Thrombosis Research Unit, University Hospital, Leiden, The Netherlands
N H van Tilburg

The Haemostasis and Thrombosis Research Unit, University Hospital, Leiden, The Netherlands
F Eulderink

²The Department of Pathology, University Hospital, Leiden, The Netherlands

Abstract

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Summary

In this paper we describe our clinical experience and results with the cuticle bleeding time test in a colony of cross-bred Labrador retrievers with severe haemophilia A. The dogs have a severe bleeding tendency with a high incidence of fatal haemorrhages in the central nervous system. Homozygous females appeared to be especially prone to this lethal complication. Factor VIII recovery and half-life determinations yielded results similar to the data from human studies. The cuticle bleeding time proved to be a good measure of the coagulation defect. The prolongation of the bleeding time could be completely abolished by administration of 10 to 15 units of canine factor VIII per kg body weight. We conclude that the cuticle bleeding time in canine haemophilia provides us with a suitable model for the in vivo study of new therapeutic materials.

Key words

Haemophilia A - Dogs - Cuticle bleeding time

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Referenzen

References
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