Abstract
Fluoroquinolones (FQs) are one of the most commonly prescribed classes of antibiotics.
Their high tissue distribution and broad-spectrum antibacterial coverage make their
use very attractive in numerous infectious diseases. Although generally well tolerated,
FQs have been associated with different adverse effects including dysglycemia and
arrhythmias. FQs have been also associated with a series of adverse effects related
to collagen degradation, such as Achilles tendon rupture and retinal detachment. Recently,
an association between consumption of FQs and increased risk of aortic aneurysm and
dissection has been proposed. This article reviews the pathogenesis of thoracic aortic
diseases, the molecular mechanism of FQ-associated collagen toxicity, and the possible
contribution of FQs to aortic diseases.
Keywords
aortic disease - aortic dissection - fluoroquinolones
