Using Plasma and Prothrombin Complex Concentrates

Jerrold H. Levy; Kamrouz Ghadimi; Nathan H. Waldron; Jean M. Connors

doi:10.1055/s-0039-1695736

Seminars in Thrombosis and Hemostasis, Inhaltsverzeichnis

Semin Thromb Hemost 2020; 46(01): 032-037
DOI: 10.1055/s-0039-1695736

Review Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Using Plasma and Prothrombin Complex Concentrates

Autor*innen

Jerrold H. Levy

¹Division of Cardiothoracic Anesthesiology and Critical Care, Department of Anesthesiology, Duke University School of Medicine, Durham, North Carolina
Kamrouz Ghadimi

¹Division of Cardiothoracic Anesthesiology and Critical Care, Department of Anesthesiology, Duke University School of Medicine, Durham, North Carolina
Nathan H. Waldron

¹Division of Cardiothoracic Anesthesiology and Critical Care, Department of Anesthesiology, Duke University School of Medicine, Durham, North Carolina
Jean M. Connors

²Department of Hematology, Harvard Medical School, Boston, Massachusetts

Abstract

Surgical patients, following procedural interventions or traumatic injury, often bleed due to ongoing blood loss or coagulopathy. Volume resuscitation and transfusion management are critical for the massively bleeding patient. While transfusions may correct coagulopathy, they carry multiple risks including circulatory overload and transfusion-related acute lung injury. Factor concentrates, specifically prothrombin complex concentrates (PCCs), are often used as part of multimodal therapy for bleeding along with laboratory testing to rapidly assess underlying coagulopathy. Although they are commonly used as part of management algorithms, studies evaluating their efficacy against fresh frozen plasma (FFP) or other potential therapies are needed. Further, PCCs are indicated to treat the coagulopathy associated with non-vitamin K oral anticoagulants in the perioperative setting. The focus of this commentary will be the perioperative use of PCCs, plasma, and FFP.

Keywords

factor concentrates - fibrinogen - fresh frozen plasma - hemorrhage - plasma - prothrombin complex concentrates

Volltext

Referenzen

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