Abstract
Pharmacological evidences have correlated a low incidence of osteoporosis, breast
cancer, cardiovascular disease, and colon cancer in Asian populations, high consumers
of soya, to the properties of soy isoflavones, more specifically to daidzein and genistein.
However, in spite of the potent biological activity, their poor water solubility has
a strong negative effect on bioavailability. In this study, an innovative technique,
nano spray drying, was used to obtain nanoparticles loaded with a soybean dry extract
while carboxymethyl cellulose was used as the excipient. The optimization of the process
conditions allowed for the manufacturing of stable nanoparticles with a mean size
of around 650 nm, a narrow size distribution, and a high encapsulation efficiency
(between 78 % and 89 %). The presence of carboxymethyl cellulose was able to stabilize
the isoflavone extract and enhance its affinity with aqueous media, strongly increasing
its permeation through biological membranes up to 4.5-fold higher than pure soy isoflavone
extract raw material and twice its homologous minispray-dried formulation. These results
are very useful for the administration of the extract, either topically or orally,
suggesting that the isoflanones extract nanoparticulate powder obtained by nano spray
drying has great potential to enhance extract bioavailability and could be used as
an ingredient to be enclosed in dietary supplements and nutraceutical and cosmeceutical
products.
Key words
Glycine max
- Fabaceae - soybean isoflavone extract - nanoparticulate powder - nano spray drying
-
in vitro permeation - sodium carboxymethyl cellulose
