Catalytic Hydration of Nitriles to Amides with Manganese Dioxide on Silica Gel

Kwang-Ting Liu; Mei-Hsiu Shih; Hsiau-Wen Huang; Chia-Juei Hu

doi:10.1055/s-1988-27684

Synthesis 1988; 1988(9): 715-717
DOI: 10.1055/s-1988-27684

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Catalytic Hydration of Nitriles to Amides with Manganese Dioxide on Silica Gel

Kwang-Ting Liu^* , Mei-Hsiu Shih, Hsiau-Wen Huang, Chia-Juei Hu

^*Department of Chemistry, National Taiwan University, Taipei 10764, Taiwan, Republic of China

Abstract

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Hydration of representative nitriles with silica gel supported manganese dioxide at the reflux temperature of hydrocarbon solvents gives the corresponding amides in good to excellent yield. Phenylacetonitrile, however, was partially oxidized to benzoylformamide. Other manganese catalyst systems were also evaluated.

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