Effects of some Components of the Essential Oil of Chamomile, Chamomilla recutita, on Histamine Release from Rat Mast Cells

Thomas Miller; Ute Wittstock; Ulrike Lindequist; Eberhard Teuscher

doi:10.1055/s-2006-957799

Planta Medica, Inhaltsverzeichnis

Planta Med 1996; 62(1): 60-61
DOI: 10.1055/s-2006-957799

Letter

Effects of some Components of the Essential Oil of Chamomile, Chamomilla recutita, on Histamine Release from Rat Mast Cells

Thomas Miller, Ute Wittstock, Ulrike Lindequist, Eberhard Teuscher

Institut für Pharmazeutische Biologie, Fachrichtung Pharmazie, Ernst-Moritz-Arndt Universität Greifswald, F.-L.-Jahn-Straße 15a, D-17489 Greifswald, Germany

Abstract

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Abstract

The influence of three compounds of the essential oil of Chamomilla recutita (L.) Rauschert on the protamine sulphate-provoked degranulation of mast cells from Lewis-1a rats was investigated. The effect was determined by measuring histamine liberation fluorometrically. Chamazulene and (-)-α-bisabolol had no distinct effects. The en-yne dicycloether partly inhibited the degranulation in concentrations above 10^-4 M.

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