Abstract
The antagonistic activity of various thiol compounds versus the cytotoxic effects
of valtrate and didrovaltrate has been evaluated on cultured hepatoma cells. Compounds
with free SH groups like cysteine, mercaptoethanol, dithioerythritol, and glutathione
were able to suppress the cytotoxicity of the valepotriates in a dose-dependent way,
whereas compounds with blocked SH groups did not antagonize these toxic effects. The
possible interactions between the valepotriates and thiol compounds are discussed.
Key words
Valepotriates - cytotoxicity - hepatoma cells - thiol compounds antagonism
