Detection of Autoantibodies against NMDA-Type Glutamate Receptor in a Patient with Recurrent Optic Neuritis and Transient Cerebral Lesions

Abstract

We describe the case of a Japanese girl with recurrent optic neuritis and transient cerebral lesions. Antibodies against N-methyl-d-aspartate (NMDA)-type glutamate receptors were detected in both serum and cerebrospinal fluid. Results of this case study suggest that the development of autoantibodies against NMDA-type glutamate receptors may play a role in the pathogenesis of central nervous system demyelinating diseases.

autoantibodies against NMDA-type glutamate receptor - recurrent optic neuritis - demyelinating disease - encephalopathy - immunoglobulin therapy

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