ABSTRACT
Neurosurgical disorders are a significant cause of nonobstetric death and disability
in pregnant women. The most common neurosurgical conditions encountered are intracranial
hemorrhage, hydrocephalus, intracranial tumors, disc rupture, and head trauma. With
modern anesthesia techniques, life-threatening problems can be very well handled with
minimal danger to the fetus. However, it is preferable to wait until the third trimester
if possible to do semielective surgery. Intracranial hemorrhage can sometimes be followed
conservatively if it is not life-threatening; shunted hydrocephalus may get worse
during the later stages of pregnancy but can usually be followed; meningiomas and
pituitary adenomas may increase in size and require urgent surgical decompression
because of apoplexy; disc ruptures can usually be treated conservatively; head trauma
should be treated in the same way as in a nonpregnant patient. This article discusses
several surgical and anesthetic issues that are important in dealing with these conditions.
KEYWORDS
Stroke in pregnancy - hydrocephalus - meningiomas - head trauma - pituitary apoplexy
- lymphocytic hypophysitis
REFERENCES
- 1
Dias M S, Sekhar L N.
Intracranial hemorrhage from aneurysms and arteriovenous malformations during pregnancy
and the puerperium.
Neurosurgery.
1990;
27
855-865
, discussion 865-866
- 2
Sadasivan B, Malik G M, Lee C, Ausman J I.
Vascular malformations and pregnancy.
Surg Neurol.
1990;
33
305-313
- 3
Robinson J L, Hall C J, Sedzimir C B.
Subarachnoid hemorrhage in pregnancy.
J Neurosurg.
1972;
36
27-33
- 4 Winn H R. Youmans Neurological Surgery. 3rd ed. Philadelphia; WB Saunders Company
2003
- 5
Shuster E A.
Epilepsy in women.
Mayo Clin Proc.
1996;
71
991-999
, Review
- 6 Greenberg M S. Handbook of Neurosurgery. 5th ed. New York; Thieme Medical Publishers
2001: 754-803
- 7
Maheut-Lourmière J, Chu Tan S.
Hydrocephalus during pregnancy with or without neurosurgical history in childhood:
practical advice for management.
Neurochirurgie.
2000;
46
117-121
- 8
Perez-Lopez C, Duran P, Isla-Guerrero A, Alvarez F.
Cerebrospinal fluid shunting and pregnancy.
Rev Neurol.
2003;
36
872-876
- 9
Cusimano M D, Meffe F M, Gentili F, Sermer M.
Management of pregnant women with cerebrospinal fluid shunts.
Pediatr Neurosurg.
1991-1992;
17
10-13
- 10
Landwehr Jr J B, Isada N B, Pryde P G, Johnson M P, Evans M I, Canady A I.
Maternal neurosurgical shunts and pregnancy outcome.
Obstet Gynecol.
1994;
83
134-137
- 11
Riffaud L, Ferre J C, Carsin-Nicol B, Morandi X.
Endoscopic third ventriculostomy for the treatment of obstructive hydrocephalus during
pregnancy.
Obstet Gynecol.
2006;
108
801-804
- 12
Idowu O E, Shokunbi M T, Amanor-Boadu S D, Roberts O A, Eyo C.
Surgical management of tuberculum sellae meningioma in a patient with a twin pregnancy:
case report.
Surg Neurol.
2004;
62
60-63
- 13
Simon R H.
Brain tumors in pregnancy.
Semin Neurol.
1988;
8
214-221
- 14 Winn H R. Youmans Neurological Surgery. 5th ed. Philadelphia; WB Saunders Company
2004
- 15
Foyouzi N, Frisbaek Y, Norwitz E R.
Pituitary gland and pregnancy.
Obstet Gynecol Clin North Am.
2004;
31
873-892
- 16
Kastelan D, Korsic M.
High prevalence rate of pituitary incidentaloma: is it associated with the age-related
decline of the sex hormones levels?.
Med Hypotheses.
2007;
69
307-309
- 17
Gemzell C, Wang C F.
Outcome of pregnancy in women with pituitary adenoma.
Fertil Steril.
1979;
31
363-372
- 18
Bronstein M D.
Prolactinomas and pregnancy.
Pituitary.
2005;
8
31-38
- 19
Heald A, Parr C, Gibson C, O'Driscoll K, Fowler H.
A cross-sectional study to investigate long-term cognitive function in people with
treated pituitary Cushing's disease.
Exp Clin Endocrinol Diabetes.
2006;
114
490-497
- 20
Molitch M E.
Pituitary gland and pregnancy.
Growth Horm IGF Res.
2003;
13(suppl A)
S38-S44
- 21
Vance M L, Thorner M O.
Prolactinomas.
Endocrinol Metab Clin North Am.
1987;
16
731-753
- 22
Lowe S A.
Diagnostic radiography in pregnancy: risks and reality.
Aust N Z J Obstet Gynaecol.
2004;
44
191-196
- 23
Creasy J L.
CT and MRI compete in diagnosis of CNS disease.
Diagn Imaging (San Franc).
1990;
12
96-101
- 24
Weinreb J C, Brown C E, Lowe T W, Cohen J M, Erdman W A.
Pelvic masses in pregnant patients.
Radiology.
1986;
159
717-724
- 25
Yamashita Y, Namimoto T, Abe Y et al..
MR imaging of the fetus by a HASTE sequence.
AJR Am J Roentgenol.
1997;
168
513-519
- 26
Bonneville J F, Bonneville F, Cattin F.
Magnetic resonance imaging of pituitary adenomas.
Eur Radiol.
2005;
15
543-548
- 27
Bronstein M D, Salgado L R, de Castro Musolino N R.
Medical management of pituitary adenomas: the special case of management of the pregnant
woman.
Pituitary.
2002;
5
99-107
- 28 Schnider S M, Levinson G.
Anaesthesia for obstetrics. In: Miller RD Anaesthesia. Vol. 2. 4th ed. New York; Churchill Livingstone 1994:
2031-2076
- 29
Claus E B, Bondy M L, Schildkraut J M, Wiemels J L, Wrensch M, Black P M.
Epidemiology of intracranial meningioma.
Neurosurgery.
2005;
57
1088-1095
- 30
Kathirgamanathan A, Jardine A D, Levy D M, Grevitt M P.
Lumbar disc surgery in the third trimester-with the fetus in utero.
Int J Obstet Anesth.
2006;
15
181-182
- 31
Inamasu J, Nichols T A, Guiot B H.
Vertebral hemangioma symptomatic during pregnancy treated by posterior decompression,
intraoperative vertebroplasty, and segmental fixation.
J Spinal Disord Tech.
2006;
19
451-454
- 32
Ahmad F U, Pandey P, Sharma B S, Garg A.
Foot drop after spinal anesthesia in a patient with a low-lying cord.
Int J Obstet Anesth.
2006;
15
233-236
Peter BlackM.D. Ph.D.
Department of Neurosurgery, Brigham and Women's Hospital
75 Francis Street, Boston, MA 02115
Email: pblack@partners.org