Effector functions of pathogenic Yersinia species

Martin Aepfelbacher; Claudia Trasak; Klaus Ruckdeschel

doi:10.1160/TH07-03-0173

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2007; 98(03): 521-529
DOI: 10.1160/TH07-03-0173

Theme Issue Article

Schattauer GmbH

Effector functions of pathogenic Yersinia species

Martin Aepfelbacher

¹Institut für Medizinische Mikrobiologie, Virologie und Hygiene, Diagnostikzentrum, Universitätsklinikum Eppendorf, Hamburg, Germany

,

Claudia Trasak

¹Institut für Medizinische Mikrobiologie, Virologie und Hygiene, Diagnostikzentrum, Universitätsklinikum Eppendorf, Hamburg, Germany

,

Klaus Ruckdeschel

¹Institut für Medizinische Mikrobiologie, Virologie und Hygiene, Diagnostikzentrum, Universitätsklinikum Eppendorf, Hamburg, Germany

› Institutsangaben

Abstract

Summary

Pathogenic species of the genus Yersinia suppress and reorient the immune system to infect lymphatic tissues, inner organs and at times also the vasculature. For this purpose yersiniae employ a type III secretion system to translocate effector proteins (Yersinia outer proteins;Yops) into immune cells.Yops often exert unique biochemical activities for modulating the activity of Rho GTP-binding proteins, focal adhesion proteins, inflammatory pathways and cell survival/apoptosis. In this review we will put emphasis on the biochemistry, cell- and infection biology ofYersinia effector Yops.

Keywords

Yersinia - Yops - Rho GTPases - signalling - anti-inflammation - apoptosis

Volltext

Referenzen

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