28 Open Surgery and Craniectomy for Malignant Stroke and ICH
Book
Editors: Bendok, Bernard R.; Batjer, H. Hunt
Title: Hemorrhagic and Ischemic Stroke
Subtitle: Medical, Imaging, Surgical, and Interventional Approaches
Print ISBN: 9781684200436; Online ISBN: 9781684203819; Book DOI: 10.1055/b000000291
2. Edition © 2025. Thieme. All rights reserved.
Thieme Medical Publishers, Inc., New York
Subjects: Neurosurgery
Thieme Clinical Collections (English Language)
Abstract
Malignant stroke is defined as a large middle cerebral artery infarct, with or without anterior and posterior territory involvement, associated with significant acute cerebral edema and high intracranial pressure. Even with best medical practice, it is associated with high mortality rates. Decompressive hemicraniectomy is a life-saving surgical intervention. The indications and timing of this procedure, while clear in some cases, can be controversial. In this chapter, we review the existing literature and evidence for surgical management of both acute ischemic stroke complicated by malignant edema and supratentorial intraparenchymal hemorrhage. Treatment of intraparenchymal hemorrhage by both direct evacuation and craniectomy alone is explored. Evidence on complications and timing of cranioplasty are also discussed. Current guidelines and recommendations for care are included.
Key words
intracranial hemorrhage - malignant stroke - craniotomy - decompressive craniectomy - cerebral edema - cranioplasty- 1 Jüttler E, Schwab S, Schmiedek P, et al. Decompressive Surgery for the Treatment of Malignant Infarction of the Middle Cerebral Artery (DESTINY): a randomized, controlled trial.. Stroke 2007; 38 (9) 2518-2525 PubMed
- 2 Jüttler E, Bösel J, Amiri H, et al. DESTINY II: DEcompressive Surgery for the Treatment of malignant INfarction of the middle cerebral arterY II.. Int J Stroke 2011; 6 (1) 79-86 PubMed
- 3 Frank JI, Schumm LP, Wroblewski K, et al. Hemicraniectomy and durotomy upon deterioration from infarction-related swelling trial: randomized pilot clinical trial.. Stroke 2014; 45 (3) 781-787 PubMed
- 4 Vahedi K, Vicaut E, Mateo J, et al. Sequential-design, multicenter, randomized, controlled trial of early decompressive craniectomy in malignant middle cerebral artery infarction (DECIMAL Trial).. Stroke 2007; 38 (9) 2506-2517 PubMed
- 5 Hofmeijer J, Kappelle LJ, Algra A, Amelink GJ, van Gijn J, van der Worp HB, . Surgical decompression for space-occupying cerebral infarction (the Hemicraniectomy After Middle Cerebral Artery infarction with Life-threatening Edema Trial [HAMLET]): a multicentre, open, randomised trial.. Lancet Neurol 2009; 8 (4) 326-333 PubMed
- 6 Alexander P, Heels-Ansdell D, Siemieniuk R et al. Hemicraniectomy versus medical treatment with large MCA infarct: a review and meta-analysis.. BMJ Open 2016; 6 (11) e014390 PubMed
- 7 Powers WJ, Rabinstein AA, Ackerson T et al. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association.. Stroke 2018; 49 (3) e46-e110 PubMed
- 8 Mendelow AD, Gregson BA, Fernandes HM, et al. Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial.. Lancet 2005; 365 (9457) 387-397 PubMed
- 9 Bhattathiri PS, Gregson B, Prasad KSM, Mendelow AD, . Intraventricular hemorrhage and hydrocephalus after spontaneous intracerebral hemorrhage: results from the STICH trial.. Acta Neurochir Suppl (Wien) 2006; 96: 65-68 PubMed
- 10 Mendelow AD, Gregson BA, Rowan EN, Murray GD, Gholkar A, Mitchell PM, . Early surgery versus initial conservative treatment in patients with spontaneous supratentorial lobar intracerebral haematomas (STICH II): a randomised trial.. Lancet 2013; 382 (9890) 397-408 PubMed
- 11 Gregson BA, Broderick JP, Auer LM et al. Individual patient data subgroup meta-analysis of surgery for spontaneous supratentorial intracerebral hemorrhage.. Stroke 2012; 43 (6) 1496-1504 PubMed
- 12 Heuts SG, Bruce SS, Zacharia BE et al. Decompressive hemicraniectomy without clot evacuation in dominant-sided intracerebral hemorrhage with ICP crisis.. Neurosurg Focus 2013; 34 (5) E4 PubMed
- 13 Hayes SB, Benveniste RJ, Morcos JJ, Aziz-Sultan MA, Elhammady MS. Retrospective comparison of craniotomy and decompressive craniectomy for surgical evacuation of nontraumatic, supratentorial intracerebral hemorrhage.. Neurosurg Focus 2013; 34 (5) E3 PubMed
- 14 Takeuchi S, Takasato Y, Masaoka H et al. Decompressive craniectomy with hematoma evacuation for large hemispheric hypertensive intracerebral hemorrhage.. Acta Neurochir Suppl (Wien) 2013; 118: 277-279 PubMed
- 15 Fung C, Murek M, Z’Graggen WJ, et al. Decompressive Hemicraniectomy in Patients with Supratentorial Intracerebral Hemorrhage. 2012. Available at: http://stroke.ahajournals.org/content/strokeaha/43/12/3207.full.pdf. Accessed April 16, 2018
- 16 Zuccarello M, Brott T, Derex L et al. Early surgical treatment for supratentorial intracerebral hemorrhage: a randomized feasibility study.. Stroke 1999; 30 (9) 1833-1839 PubMed
- 17 Pantazis G, Tsitsopoulos P, Mihas C, Katsiva V, Stavrianos V, Zymaris S. Early surgical treatment vs conservative management for spontaneous supratentorial intracerebral hematomas: a prospective randomized study.. Surg Neurol 2006; 66 (5) 492-501, discussion 501–502 PubMed
- 18 Morgenstern LB, Demchuk AM, Kim DH, Frankowski RF, Grotta JC. Rebleeding leads to poor outcome in ultra-early craniotomy for intracerebral hemorrhage.. Neurology 2001; 56 (10) 1294-1299 PubMed
- 19 Hemphill III JC, Greenberg SM, Anderson CS, et al. , , Guidelines for the management of spontaneous intracerebral hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association.. Stroke 2015; 46 (7) 2032-2060 PubMed
- 20 Borger V, Schuss P, Kinfe TM, Vatter H, Güresir E. Decompressive craniectomy for stroke: early cranioplasty is a predictor for postoperative complications.. World Neurosurg 2016; 92: 83-88 PubMed
- 21 Finger T, Prinz V, Schreck E et al. Impact of timing of cranioplasty on hydrocephalus after decompressive hemicraniectomy in malignant middle cerebral artery infarction.. Clin Neurol Neurosurg 2017; 153: 27-34 PubMed
- 22 Piedra MP, Ragel BT, Dogan A, Coppa ND, Delashaw JB. Timing of cranioplasty after decompressive craniectomy for ischemic or hemorrhagic stroke.. J Neurosurg 2013; 118 (1) 109-114 PubMed
- 23 Zheng WJ, Li LM, Hu ZH et al. Excessive hemostasis on the scalp increases superficial surgical site infection rate in cranioplasty.. World Neurosurg 2018; 120: e811-e817 PubMed