40.1. 1.5.4.5 Substitution on the Amine Nitrogen (Update 2013)
Book
Editors: Banert, K.; Drabowicz, J.; Oestreich, M.; Plietker, B. J.; Ramsden, C.; Schaumann, E.; Stoltz, B. M.; Weinreb, S. M.
Title: Knowledge Updates 2013/2
Print ISBN: 9783131727619; Online ISBN: 9783132401440; Book DOI: 10.1055/b-003-128236
1st edition © 2013 Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart
Subjects: Organic Chemistry;Chemical Reactions, Catalysis;Organometallic Chemistry
Science of Synthesis Knowledge Updates
Parent publication
Title: Science of Synthesis
DOI: 10.1055/b-00000101
Series Editors: Carreira, E. M.; Decicco, C. P.; Fürstner, A.; Molander, G. A.; Reider, P. J.; Schaumann, E.; Shibasaki, M.; Thomas, E. J.; Trost, B. M.
Type: Multivolume Edition
Abstract

This chapter is an update to the earlier Science of Synthesis contribution that describes methods for the dealkylation and substitution of amines. It focuses on the literature published up to early 2012.
Key words
alkylation - amination - amine N-oxides - amines - dealkylation - C—N bond cleavage - C—N bond formation- 11 Yu H, Prisinzano T, Dersch CM, Marcus J, Rothman RB, Jacobson AE, Rice KC. Bioorg. Med. Chem. Lett. 2002; 12: 165
- 38 Han SY, Sweeney JE, Bachman ES, Schweiger EJ, Forloni G, Coyle JT, Davis BM, Joullié MM. Eur. J. Med. Chem. 1992; 27: 673
- 50 Marton J, Simon C, Hosztafi S, Szabó Z, Márki Á, Borsodi A, Makleit S. Bioorg. Med. Chem. 1997; 5: 369
- 52 Lauterbach EH, Dinkel T, Heller S, Bertogg A. US 2009 0 163 717, 2009 Chem. Abstr.. 2009 151 78313
- 61 Bähn S, Tillack A, Imm S, Mevius K, Michalik D, Hollmann D, Neubert L, Beller M. ChemSusChem 2009; 2: 551
- 63 Hamid MHSA, Allen CL, Lamb GW, Maxwell AC, Maytum HC, Watson AJA, Williams JMJ. J. Am. Chem. Soc. 2009; 131: 1766
- 73 Sreedhar B, Surendra Reddy P, Amarnath Reddy M, Neelima B, Arundhathi R. Tetrahedron Lett. 2007; 48: 8174