Abstract
The relationship between high triglyceride values and alterations of the fibrinolytic
system in cardiovascular heart disease (CHD) patients is well known. The aim of the
study was to evaluate the effect of moderate hypertriglyceridemia on fibrinolysis,
lipoprotein(a) [(Lp(a)], and platelet activation indexes in asymptomatic patients.
To this end, 46 nondiabetic, dyslipidemic patients (age 51 ± 8 years), with no associated
pathologies and 23 normolipidemic, homogeneus patients (in terms of age, sex, and
smoke habits) were studied. The dyslipidemic patients were split up into two groups:
23 type IIb hyperlipoproteinemia patients (Group I), and 23 type IIa hyperlipoproteinemia
patients (Group 2). The control group had total cholesterol values of < 5.18 mmol/L
and triglyceride concentrations of < 2.25 mmol/L. The result showed a significant
difference (p < 0.05) in the baseline plasminogen tissue activator inhibitor (PAI-1 b) values for
the Group 1 patients as compared with the Group 2 and the controls, in the baseline
tissue plasminogen activator (t-PA b) values for the Group 1 patients as compared
with the Group 2 patients and in the lipoprotein (a) (Lp(a)) (p < 0.01) values for the Group 2 as compared with the controls. On the other hand,
no statistically significant difference was observed in β-thromboglobulin (β-TG),
platelet factor 4 (PF4). This study shows that mild hypertriglyceridemia in asymptomatic
hypercholesterolemic patients is associated with a different regulation of the fibrinolytic
mechanism. In patients with moderate hypercholesterolemia, higher blood concentrations
of Lp(a) were found than in the controls.
