Cytokine responses in low-risk coronary artery bypass surgery

Minxin Wei; Pekka Kuukasjärvi; Jari Laurikka; Erkki Pehkonen; Seppo Kaukinen; Seppo Laine; Matti Tarkka

doi:10.1007/BF01616340

International Journal of Angiology, Table of Contents

Int J Angiol 2001; 10(1): 27-30
DOI: 10.1007/BF01616340

Original Articles

Cytokine responses in low-risk coronary artery bypass surgery

Minxin Wei¹ , Pekka Kuukasjärvi¹ , Jari Laurikka¹ , Erkki Pehkonen¹ , Seppo Kaukinen² , Seppo Laine³ , Matti Tarkka¹

¹Division of Cardiovascular Surgery, Tampere University Hospital, Tampere, Finland
²Department of Anesthesia and Intensive Care, Tampere University Hospital, Tampere, Finland
³Department of Clinical Chemistry, Tampere University Hospital, Tampere, Finland

Abstract

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Abstract

Inflammatory cytokines have been implicated in myocardial function, severe congestive heart failure and sepsis. The present study tested the hypothesis that cytokine levels are elevated after low-risk coronary artery bypass surgery (CABG), and that they may be associated with postoperative cardiac dysfunction. Twenty male patients undergoing elective CABG in cardiopulmonary bypass (CPB) were studied. Plasma levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-6, IL-8, and IL-10 were measured before anesthesia induction, 5 minutes after, and 1, 4, and 20 hours after reperfusion to the myocardium. Levels of the MB isoenzyme of creatine kinase (CK-MB) were measured postoperatively. Hemodynamic data were also recorded. Myocardial ischemia was followed by an increase in the plasma levels of IL-6, IL-8, and IL-10. The duration of IL-6 response lasted throughout the postoperative period studied. Plasma cytokine levels at 1 hour after reperfusion correlated with the maximum CK-MB value (IL-6, r=0.587, p < 0.01; IL-8, r=0.460, p < 0.05; IL-10, r=0.570, p < 0.05). Higher plasma IL-6 and IL-8 levels after reperfusion tended to be linked with lower cardiac index. The present results confirm that the levels of inflammatory cytokines IL-6, IL-8, and IL-10 are elevated after CABG. Increased systemic pro-inflammatory cytokine levels were partially associated with postoperative myocardial dysfunction.

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