Abstract
Samuel Hahnemann attributed fundamental importance to the principle of similitude,
promoting it to a ‘natural law’. Observing that enantiopathic or allopathic treatment
produced enduring aggravation of the disease symptoms after a brief and transitory
initial relief, he systematised homeopathic treatment, prescribing substances that
provoke similar symptoms in healthy individual. Based on clinical and experimental
observations, he anticipated the concept of homeostasis, dividing the effects of substances
into: primary action of the medicine followed by secondary action or reaction of the
organism. This reaction, known as the rebound effect or paradoxical action by modern
pharmacology, used to awake the curative response of the body when the principle of
similitude is applied, is responsible for several iatrogenic diseases when used on
the basis of the principle of contraries. This study discusses the role of this paradoxical
reaction of the organism in the fatal side effects of four important drugs, used according
to the model of enantiopathic treatment of the symptoms. I present evidence relating
to acetylsalicylic acid, rofecoxib, antidepressants and long-acting bronchodilators.
The consequences of the allopathic treatment could be decreased if health professionals
valued homeostasis, minimising the rebound effect of the organism by gradual suspension
of palliative drugs.
Keywords
similitude - homeostasis - rebound effect - paradoxical reaction - compensatory response
- fatal iatrogenic event