Clinical management of babesiosis in dogs with homeopathic Crotalus horridus 200C

S. Chaudhuri; J.P. Varshney

doi:10.1016/j.homp.2007.02.010

Homeopathy, Inhaltsverzeichnis

Homeopathy 2007; 96(02): 90-94
DOI: 10.1016/j.homp.2007.02.010

Original Paper

Clinical management of babesiosis in dogs with homeopathic Crotalus horridus 200C

Autor*innen

S. Chaudhuri
J.P. Varshney

Clinical Diagnosis laboratory, Referral Veterinary Polyclinic, Indian Veterinary Research Institute, Izatnagar 243122 UP, India

Abstract

Homeopathic Crotalus horridus 200C was evaluated in 13 clinical cases of babesiosis in dogs, compared with another 20 clinical cases treated with diminazine. Babesiosis is an important tropical tick-borne haemoprotozoan disease in dogs clinically manifested by anorexia, dehydration, temperature, dullness/depression, diarrhoea/constipation, pale mucosa, hepatomegaly, vomiting/nausea, splenomegaly, distended abdomen/ascites, yellow coloured urine, emaciation/weight loss, and occular discharge. The diagnosis of babesiosis was based on cytological evidence of Babesia gibsoni in freshly prepared blood smears. The dogs were treated with oral C. horridus 200C, 4 pills four times daily for 14 days (n=13) or diminazine aceturate 5 mg/kg single intramuscularly dose (n=20). All the dogs were administered 5% Dextrose normal saline at 60 ml/ kg intravenously for 4 days.

Initial clinical scores were similar in both groups and showed similar progressive improvement with the two treatments over 14 days. Parasitaemia also improved in both groups, but haematological values showed no change.

No untoward reactions were observed. It appears that C. horridus is as effective in causing clinical recovery in moderate cases of canine babesiosis caused by Babesia gibsoni as the standard drug diminazine. Large scale randomized trials are indicated for more conclusive results.

Keywords

Babesiosis - B. gibsoni - Crotalus horridus - dog

Volltext

Referenzen

References
1 Kalra I.S., Singh K.B. Observations of naturally occurring Babesia canis infection in dog. Indian Vet J 1984; 61: 98-100.
2 Varshney J.P., Kumar A., Hoque M. Ehrlichia platys and Babesia canis infection in a dog: a clinical report. J Vet Parasitol 2004; 18: 35-37.
3 Sinha B.P., Ghosh P. Treatment of clinical cases of canine babesiosis. Indian J Vet Med 1986; 6: 94.
4 Verma S.P., Srivastava P.S., Sinha S.R.P., Sinha B.P., Sinha V.K. An outbreak of canine babesiosis in police dog squad of Patna. Indian J Anim Health 1989; 28: 47-49.
5 Varshney J.P., Dey S. A clinical study on haemoprotozoan infections in referral canines. J Remount Vet Crop 1998; 37: 83-89.
6 Varshney J.P., Varshney V.P., Hoque M. Clinico-haematological, biochemical endocrinological and ultrasonographic findings in canine babesiosis. Indian J Anim Sci 2003; 73: 1099-1101.
7 Chaudhuri, S. Studies on clinico-therapeutic aspects of babesiosis in dogs. MVSc Thesis, submitted to Indian Veterinary research Institute, Izatnagar, India 2006.
8 Saud N., Hazarika G.C. Studies on the incidence and biochemical changes of babesia infection in dogs. Indian Vet J 2000; 77: 944-947.
9 Purnell R.E. Babesiosis in various hosts. Ristic M., Kreier J.P. Babesiosis. 1981. New York: Academic Press Inc.; 25-63
10 Aragon R.S. Bovine babesiosis—a review. Vet Bull 1976; 46: 903-917.
11 Dakshinkar N.P., Bhojne G.R. Chronic canine babesiosis. Indian J Vet Med 2002; 22: 59-60.
12 Bauer F. Chemotherapy of Babesia gibsoni infection in the dog. Zentra Ibl. Vet Med 1967; 14: 170-178.
13 Farwell G.E., Le Grand E.K., Cobb C.C. Clinical observation on Babesia gibsoni and Babesia canis infections in dogs. J Am Vet Med Assoc 1982; 180: 507-511.
14 Boozer A.L., Macintire D.K. Canine babesiosis. Vet Clin North Am Small Anim Prac 2003; 33: 885-904.
15 Conard P., Thomford M.S., Yamane I., Bosma L., Uno T., Holshuly H.J. et al. Haemolytic anaemia caused by Babesia gibsoni infection in dogs. J Am Vet Med Assoc 1991; 199: 601-605.
16 Adeyanju B.J., Aliu Y.O. Chemotherapy of canine ehrlichiosis and babesiosis with imidocarb dipropionate. J Am Anim Hosp Assoc 1982; 18: 827-830.
17 Macleod G. The Treatment of Cattle by Homeopathy. Saffron Walden, England: The C. W. Daniel Company Ltd; 1981.
18 Jain N.C. Schalm's Veterinary Haematology. fourth edition. Philadelphia: Lee and Febiger; 1986. pp 36–53
19 Irwin P.J., Hutchinson C.W. Clinical and pathological findings of babesia infection in dogs. Aust Vet J 1991; 68: 204-209.
20 Fowler J.L., Michael M.S., Ruff D., Fernan R.C., Furusho Y. Babesia gibsoni: chemotherapy in dogs. Am J Vet Res 1972; 33: 1109-1114.
21 Itoh N., Hieguchi S., Kawanusah S. The effect of diminazine aceturate on splenectomized dogs with Babesia gibsoni infection. Vet Clin Pathol 1988; 17: 94-98.
22 Murphy R. Lotus Materia Medica. Indian edn. New Delhi: B. Jain Publishers Pvt. Ltd.; 2002.
23 Wulansari R., Wijaya A., Ano H., Horii Y., Makimura S. Lymphocyte subsets and specific IgG antibody levels in clindamyin treated and untreated dogs experimentally infected with Babesia gibsoni . J Vet Med Sci 2003; 65: 579-587.