Homeopathy 2013; 102(01): 49-53
DOI: 10.1016/j.homp.2012.11.001
Original Paper
Copyright © The Faculty of Homeopathy 2012

Effect of the oral administration homeopathic Arnica montana on mitochondrial oxidative stress

Ronaldo Antônio de Camargo
Ellen Dias da Costa
Rosana Catisti

Verantwortlicher Herausgeber dieser Rubrik:
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Received09. Dezember 2011
revised22. Oktober 2012

accepted07. November 2012

17. Dezember 2017 (online)

Objective: To analyze the effect of homeopathic Arnica on mitochondrial oxidative stress induced by Ca2+ plus inorganic phosphate and/or Fe2+-citrate-mediated lipid peroxidation through changes in oxygen consumption rates.

Methods: Mitochondria were isolated by differential centrifugation from the livers of adult male Wistar rats which had been treated with Arnica montana 6cH, 12cH, 30cH or succussed 30% ethanol (control) for 21 days.

Results: In the presence of antimycin-A, electron transport chain inhibitor, as evidenced by antimycin-A insensitive O2 consumption, Arnica inhibited lipid peroxidation of mitochondrial membranes. In oxidative stress conditions, in the presence of Ca2+ and inorganic phosphate, animals receiving Arnica 30cH had a significant decrease in mitochondrial O2 consumption compared to control animals.

Conclusion: When administrated orally, Arnica 30cH protects against hepatic mitochondrial membrane permeabilization induced by Ca2+ and/or Fe2+-citrate-mediated lipid peroxidation and fragmentation of proteins due to the attack by reactive oxygen species.