CC BY-NC-ND 4.0 · International Journal of Epilepsy 2017; 04(01): 031-035
DOI: 10.1016/j.ijep.2017.01.004
Original article
Thieme Medical and Scientific Publishers Private Ltd.

A hospital based cross sectional study on comorbid psychiatric problems in persons with epilepsy from north eastern part of India

Sajjadur Rehman
a   Dept. of Psychiatry, Lady Hardinge Medical College New Delhi, 110001, India
,
Kamal K. Kalita
b   Dept. of Psychiatry, LGB Regional Institute of Mental Health Tezpur, Assam, 784001, India
,
Aparajeeta Baruah
c   Dept. of Psychiatry, LGB Regional Institute of Mental Health Tezpur, Assam, 784001, India
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Publikationsverlauf

Received: 29. Dezember 2016

Accepted: 27. Januar 2017

Publikationsdatum:
06. Mai 2018 (online)

Abstract

Context The relationship between epilepsy and psychiatric disorders has been recognized for a long time. Psychiatric disturbances like depression, anxiety disorder, psychosis, panic disorder, suicidal behavior etc are associated with epilepsy. Different demographic and clinical factors are associated with the onset of these psychiatric disturbances.

Aims To study the prevalence of psychiatric comorbidity in persons with epilepsy. Also assess the different demographic and clinical factors and its relation with the presence of psychiatric comorbidity in persons with epilepsy.

Settings and design It was a cross sectional observational study.

Methods and material Diagnosed cases of epilepsy, attending Epilepsy Clinic, fulfilling the inclusion and exclusion criteria were recruited for the study. Patients were evaluated with Mini International Neuropsychiatric Interview (MINI) to see their psychiatric comorbidities and also the socio-demographic and clinical factors were assessed

Statistical analysis used SPSS version 23.0 for Windows and Graph Pad InStat software trial version 3.1 was used for analysis.

Results Psychiatric comorbidity was seen in 50% subjects with comorbid with epilepsy. Depression 18%, Psychosis 14% and Anxiety Disorders 11%, were the most commonly found psychiatric morbidities. Presence of partial seizures, frequent seizures, long duration of epilepsy and poor compliance to antiepileptic drug were significantly associated with presence of psychiatric comorbidity in persons with epilepsy.

Conclusions Psychiatric comorbidities are very common in epilepsy. Psychosis associated with epilepsy is seen more in hospital settings. Depression and anxiety though commonly reported in studies are less commonly presented to tertiary care settings.

 
  • References

  • 1 Kanner AM. Psychiatric issues in epilepsy: the complex relation of mood, anxiety disorders, and epilepsy. Epilepsy Behav 15 (01) 2009; 83-87
  • 2 Manchanda R. Psychiatric disorders in epilepsy: clinical aspects. Epilepsy Behav 3 (01) 2002; 39-45
  • 3 Hermann BP, Seidenberg M, Bell B. Psychiatric comorbidity in chronic epilepsy: identification, consequences, and treatment of major depression. Epilepsia 41 Suppl. (02) 2000; S31-41
  • 4 Gaitatzis A, Trimble MR, Sander JW. The psychiatric comorbidity of epilepsy. Acta Neurol Scand 110 (04) 2004; 207-220
  • 5 Titlic M, Basic S, Hajnsek S, Lusic I. Comorbidity psychiatric disorders in epilepsy: a review of literature. Bratisl Lek Listy 110 (02) 2009; 105-109
  • 6 Jacob R, Tharyan P. Psychiatric comorbidity and quality of life in people with epilepsy. Ger J Psychiatry 13 (02) 2010; 79-85
  • 7 Swinkels WA, Kuyk J, van Dyck R, Spinhoven P. Psychiatric comorbidity in epilepsy. Epilepsy Behav 7 (01) 2005; 37-50
  • 8 Robertson MM, Trimble MR, Townsend HR. Phenomenology of depression in epilepsy. Epilepsia 28 (04) 1987; 364-372
  • 9 Jones JE, Hermann BP, Barry JJ, Gilliam F, Kanner AM, Meador KJ. Clinical assessment of Axis I psychiatric morbidity in chronic epilepsy: a multicenter investigation. J Neuropsychiatry Clin Neurosci 17 (02) 2005; 172-179
  • 10 Proposal for revised clinical and electroencephalographic classification of epileptic seizures. From the Commission on Classification and Terminology of the International League Against Epilepsy. Epilepsia 1981; 22 (04) 489-501
  • 11 Sheehan DV, Lecrubier Y, Sheehan KH. et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Neuropsychiatry Clin Neurosci 59 Suppl. (20) 1998; 22-33 quiz 4–57
  • 12 Cramer JA, Roy A, Burrell A. et al. Medication compliance and persistence: terminology and definitions. Value Health 11 (01) 2008; 44-47
  • 13 Mendizabal JE, Salguero LF. Prevalence of epilepsy in a rural community of Guatemala. Epilepsia 37 (04) 1996; 373-376
  • 14 Radhakrishnan K, Pandian JD, Santhoshkumar T. et al. Prevalence, knowledge, attitude, and practice of epilepsy in Kerala, South India. Epilepsia 41 (08) 2000; 1027-1035
  • 15 Currie S, Heathfield KW, Henson RA, Scott DF. Clinical course and prognosis of temporal lobe epilepsy. A survey of 666 patients. Brain 94 (01) 1971; 173-190
  • 16 Edeh J, Toone B. Relationship between interictal psychopathology and the type of epilepsy: results of a survey in general practice. Br J Psychiatry 151 1987; 95-101
  • 17 Manchanda R, Schaefer B, McLachlan RS. et al. Psychiatric disorders in candidates for surgery for epilepsy. J Neurol Neurosurg Psychiatry 61 (01) 1996; 82-89
  • 18 Cyriac N, Sureshkumar PN, Kunhikoyamu AM, Girija AS. Social factors and psychopathology in epilepsy. Neurol India 50 (02) 2002; 153-157
  • 19 Amruth G, Praveen-Kumar S, Nataraju B, Kasturi P. Study of psychiatric comorbidities in epilepsy by using the Mini International Neuropsychiatric Interview. Epilepsy Behav 33 2014; 94-100
  • 20 Desai S, Shukla G, Goyal V. et al. Changes in psychiatric comorbidity during early postsurgical period in patients operated for medically refractory epilepsy–a MINI-based follow-up study. Epilepsy Behav 32 2014; 29-33
  • 21 Schmitz B, Wolf P. Psychosis in epilepsy: frequency and risk factors. J Epilepsy 8 (04) 1995; 295-305
  • 22 Filho GM, Rosa VP, Lin K, Caboclo LO, Sakamoto AC, Yacubian EM. Psychiatric comorbidity in epilepsy: a study comparing patients with mesial temporal sclerosis and juvenile myoclonic epilepsy. Epilepsy Behav 13 (01) 2008; 196-201
  • 23 Perini GI, Tosin C, Carraro C. et al. Interictal mood and personality disorders in temporal lobe epilepsy and juvenile myoclonic epilepsy. J Neurol Neurosurg Psychiatry 61 (06) 1996; 601-605
  • 24 Babu CS, Satishchandra P, Sinha S, Subbakrishna DK. Co-morbidities in people living with epilepsy: hospital based case-control study from a resource-poor setting. Epilepsy Res 86 (02) (03) 2009; 146-152
  • 25 Faught E, Duh MS, Weiner JR, Guerin A, Cunnington MC. Nonadherence to antiepileptic drugs and increased mortality: findings from the RANSOM Study. Neurol 71 (20) 2008; 1572-1578
  • 26 Bragatti JA, Torres CM, Londero RG. et al. Prevalence of psychiatric comorbidities in temporal lobe epilepsy in a Southern Brazilian population. Arq Neuro Psiquia 69 2011; 159-165