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Indian Journal of Neurotrauma 2013; 10(02): 80-85
DOI: 10.1016/j.ijnt.2013.10.006
Original Article
Thieme Medical and Scientific Publishers Private Ltd.

Brain morphometric changes and cognitive domain correlations in early mild to moderate traumatic brain injury

Ashok Munivenkatappa
a   Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
,
Indira D. Bhagavatula
a   Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
,
Dhaval Shukla
a   Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
,
Neeraj Upadhyay
a   Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
,
Shobini L. Rao
b   Department of Clinical Psychology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
,
D.K. Subbakrishna
c   Department of Biostatistics, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
,
Jamuna Rajeswaran
b   Department of Clinical Psychology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
,
Rose D. Thomas
d   Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
› Author Affiliations
Subject Editor:
Further Information

Publication History

16 July 2012

23 October 2013

Publication Date:
06 April 2017 (online)

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Abstract

Background

TBI is associated with whole brain volume and thickness loss based on validated volumetric methods using MRI images.

Aims

To look for early psychological and concussion symptoms correlation with volumetric data.

Methods

We used FreeSurfer software to identify significant clusters using minimum 2 thresholds, FDR 0.15 and simulation 0.01.

Results

There was no significant regions of 22 TBI patients (mean 27.7 years) compared to 20 (mean 27.1 years) age and gender match controls approximately 13 weeks of brain injury. Among TBI patients significant decrease in cortical volume and thickness was seen.

Conclusion

Few psychological domains showed significant clusters with weak correlation.

Keywords

Traumatic brain injury - Brain measures - Volume and thickness
 

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