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Int J Sports Med 2018; 39(06): 482-489
DOI: 10.1055/a-0592-7691
Genetics & Molecular Biology
© Georg Thieme Verlag KG Stuttgart · New York

microRNAs in High and Low Responders to Resistance Training in Breast Cancer Survivors

Amanda D. Hagstrom
1   University of New England, Science and Technology, Armidale, Australia
,
Joshua Denham
1   University of New England, Science and Technology, Armidale, Australia
2   RMIT University, School of Health and Biomedical Sciences, Melbourne, Australia
› Author Affiliations
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Publication History



accepted 28 February 2018

Publication Date:
26 April 2018 (online)

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Abstract

Accounting for one in three cancer diagnoses, breast cancer is the second most commonly diagnosed cancer in women. Exercise has a well-accepted role in the multi-disciplinary approach to rehabilitating breast cancer survivors. Despite the many known benefits of resistance training on women recovering from breast cancer, the molecular mechanisms are poorly understood. MicroRNAs are small non-coding RNAs that have crucial roles in growth and development. Here, we analysed the abundance of 9 miRNAs, with known roles in muscle physiology and some linked to cancer, in serum samples from 24 breast cancer survivors before and after a 16-week resistance training or usual care intervention. The resistance training group completed supervised thrice-weekly training. miRNA abundance was assessed before and after the intervention period using qPCR. There were no statistically significant changes in any of the miRNAs between groups after the intervention period (all p>0.05). After assessing miRNA abundance in context with high and low responders to resistance training, we observed that relative to low responders, high responders exhibited increased miR-133a-3p and a borderline statistically significant increase in miR-370-3p. Findings from our controlled study indicate the diverse interindividual miRNA responses to resistance training and reveal a discordant regulation between high and low responders.

Key words

miRNA - muscle strength - miRNA-133a - exercise - small non-coding RNA
 

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