Planta Med 2018; 84(14): 1055-1063
DOI: 10.1055/a-0593-6030
Natural Product Chemistry and Analytical Studies
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Botryane Sesquiterpenoids, Cyclopentadepsipeptides, Xanthones, and Trichothecenes from Trichoderma oligosporum

Baosong Chen*
1  State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, P. R. China
2  Savaid Medicine School, University of Chinese Academy of Sciences, Beijing, P. R. China
,
Erwei Li*
1  State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, P. R. China
,
Li Liu
1  State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, P. R. China
2  Savaid Medicine School, University of Chinese Academy of Sciences, Beijing, P. R. China
,
Mingfang Liao
1  State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, P. R. China
2  Savaid Medicine School, University of Chinese Academy of Sciences, Beijing, P. R. China
,
Zhaoxiang Zhu
1  State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, P. R. China
,
Wenying Zhuang
1  State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, P. R. China
,
Li Bao
1  State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, P. R. China
,
Hongwei Liu
1  State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, P. R. China
2  Savaid Medicine School, University of Chinese Academy of Sciences, Beijing, P. R. China
› Author Affiliations
Further Information

Publication History

received 02 October 2017
revised 28 February 2018

accepted 14 March 2018

Publication Date:
22 March 2018 (online)

Abstract

Five new botryane sesquiterpenes (15), one new cyclopentadepsipeptide (9), and two new xanthones (11 – 12), together with 11 known compounds, were isolated from Trichoderma oligosporum. The structures of the new compounds were identified by comprehensive spectroscopic methods including nuclear magnetic resonance and mass spectrometry. The cytotoxicity of 119 was evaluated against K562, A549, and ASPC cell lines. Compounds 5, 8, 11, 17, and 18 showed cytotoxicity against the K562 cell line with more than 50% inhibition at 12.5 µM. As to A549 cell line, compound

8 showed the strongest cytotoxicity with approximately 50% inhibition at 25.0 µM. No compounds showed cytotoxicity against the ASPC cell line.

* These authors contributed equally to this work.


Supporting Information