Endoscopy 2018; 50(11): 1105-1111
DOI: 10.1055/a-0625-6440
Innovations and brief communications
© Georg Thieme Verlag KG Stuttgart · New York

A novel endoscopic ultrasound-guided through-the-needle microbiopsy procedure improves diagnosis of pancreatic cystic lesions

Bojan Kovacevic
1  Gastro Unit, Division of Endoscopy, Copenhagen University Hospital, Herlev, Denmark
,
Pia Klausen
1  Gastro Unit, Division of Endoscopy, Copenhagen University Hospital, Herlev, Denmark
,
Jane Preuss Hasselby
2  Department of Pathology, Copenhagen University Hospital, Rigshospitalet, Denmark
,
John Gásdal Karstensen
1  Gastro Unit, Division of Endoscopy, Copenhagen University Hospital, Herlev, Denmark
3  Gastro Unit, Division of Surgery, Copenhagen University Hospital, Hvidovre, Denmark
,
Charlotte Vestrup Rift
2  Department of Pathology, Copenhagen University Hospital, Rigshospitalet, Denmark
,
Evangelos Kalaitzakis
1  Gastro Unit, Division of Endoscopy, Copenhagen University Hospital, Herlev, Denmark
,
Anders Toxværd
4  Department of Pathology, Copenhagen University Hospital, Herlev, Denmark
,
Carsten Palnæs Hansen
5  Department of Gastrointestinal Surgery, Copenhagen University Hospital, Rigshospitalet, Denmark
,
Jan Storkholm
5  Department of Gastrointestinal Surgery, Copenhagen University Hospital, Rigshospitalet, Denmark
,
Hazem Hassan
1  Gastro Unit, Division of Endoscopy, Copenhagen University Hospital, Herlev, Denmark
,
Peter Vilmann
1  Gastro Unit, Division of Endoscopy, Copenhagen University Hospital, Herlev, Denmark
› Author Affiliations
Further Information

Publication History

submitted 30 November 2017

accepted after revision 19 April 2018

Publication Date:
06 July 2018 (eFirst)

Abstract

Background Pancreatic cystic lesions represent a diagnostic dilemma as some may harbor malignancy or have potential for malignant transformation. The aim of this study was to present our experience with a novel endoscopic ultrasound (EUS)-guided microbiopsy procedure enabling procurement of tissue from the wall of the cystic lesion.

Methods We collected data from 31 consecutive patients with pancreatic cystic lesions who underwent an EUS-guided microbiopsy procedure at our institution. Records were retrospectively reviewed from a prospectively maintained database.

Results The technical success was 87.1 %. Diagnostic yield of microbiopsies was 71.0 %. Microbiopsies offered sufficient tissue for morphological and immunohistochemical characterization of the lesions, as well as determination of grade of dysplasia. Furthermore, evaluation of microbiopsies changed the clinical management in six patients (19.4 %). Three nonsevere adverse events were observed (9.7 %): two cases of mild infection and one case of mild pancreatitis. All three patients recovered completely.

Conclusions EUS-guided microbiopsy procedure was technically feasible, with a high diagnostic yield. Further prospective studies are needed to confirm these promising results.