Abstract
The association between diabetes and depression is well recognised. Similarly, diabetic
peripheral neuropathy (DPN) is a frequent complication of diabetes. Given the high
prevalence of these conditions individually, it is hardly surprising they frequently
interact, conferring additional morbidity and a higher mortality risk. Despite this,
the specific clinical characteristics that underpin co-morbid depression and DPN remain
unclear. Additionally, there is insufficient insight into causal pathways and temporal
trends. High-quality epidemiological data is limited, but they suggest that these
conditions may share certain common risk factors, although there are also distinct
differences such as gender. Improved insights into the risk factors for the co-existence
of DPN and depression may help towards improved screening for and treatment of these
conditions.