Int J Sports Med 2019; 40(05): 354-358
DOI: 10.1055/a-0824-5394
Genetics & Molecular Biology
© Georg Thieme Verlag KG Stuttgart · New York

KCNA4 Gene Variant is Auxiliary in Endurance Running Performance Level

Keven Flecha-Velazquez
1  Department Physical Medicine, Rehabilitation & Sports Medicine, University of Puerto Rico School of Medicine, San Juan, Puerto Rico
,
Thomas D. Fahey
2  Department Kinesiology, California State University - Chico, Chico, United States
,
Juan L. Martínez
3  Sinaloense Sports Institute, Sport Medicine and Applied Sciences Unit, Culiacan, Mexico
,
Juan R. Lopez-Taylor
4  Universidad de Guadalajara, Physical Activity and Applied Sport Sciences Institute, Guadalajara, Mexico
,
Miguel A. Rivera
1  Department Physical Medicine, Rehabilitation & Sports Medicine, University of Puerto Rico School of Medicine, San Juan, Puerto Rico
› Author Affiliations
Further Information

Publication History

Publication Date:
27 February 2019 (eFirst)

Abstract

The present is an observational study following a genetic epidemiology model using a case-control design. We tested the hypothesis of an association between the prevalence of the genotypic and allelic frequencies distribution of the potassium voltage-gated channel of the shaker related subfamily member 4 gene (KCNA4) rs1323860 (C/T transition) and endurance performance level in Hispanic male marathon runners (MR). The subjects (n=1876) were adult Hispanic male MR. Fast-MR (cases; n=938) were finishers in the top 3rd percentile. Slow MR (controls; n=938) were finishers in the lowest 3rd percentile of their respective age. Genomic DNA was purified from a whole blood sample. Polymerase chain reaction was used to amplify a KCNA4 SNP which consists of a C/T (rs1323860) transition. The observed genotype frequencies, in both Cases and Controls, met Hardy-Weinberg equilibrium (X2, P≥0.05). Genotype and allele frequencies were statistically different (P<0.01) between cases and controls. Odds ratio revealed that the C allele was 1.33 times more likely prevalent in the cases than in the controls (95% CI; 1.17, 1.51; P<0.001). The magnitude of the statistical power for the present study was 0.86. In conclusion, the findings strongly suggest that KCNA4 gene rs1323860 (C/T transition) is auxiliary in the complex phenotype of endurance running performance level in Hispanic male marathon runners.