Abstract
Aims CTRP6, a newly discovered adipokine, has been found to be a regulator for energy
homeostasis. However, the association between circulating CTRP6 and obesity in humans
is still unclear.
Methods 256 individuals, including 185 overweight/obese (OW/OB) and 71 normal weight adults,
were recruited for this study. Circulating concentrations of CTRP6 and adiponectin
(Adipoq) were examined by ELISA.
Results Serum CTRP6 levels in obese individuals were significantly increased compared with
those in healthy individuals (506.1±134.9 vs.363.3±80.5 ng/mL, P<0.01). Conversely,
serum Adipoq concentrations in OW/OB individuals were markedly decreased compared
with healthy controls [20.8 (12.1–29.3) vs. 14.1
(
8.61–17.7)
;
P<0.01]. Correlation analysis revealed that there was a positive relationship between
circulating CTRP6 and age, BMI, Fat%, LDL-C, TG, WHR, TC, FBG, FIns, HOMA-IR and HbA1c,
but there was an inverse correlation with Adipoq and HDL-C. Logistic regression analysis
revealed that high serum CTRP6 levels are markedly associated with OW/OB. Finally,
ROC curve analysis showed that the cut-off value for serum CTRP6 for prediction of
IR is 518 ng/mL.
Conclusions CTRP6 may be a marker related to OW/OB.
Key words
Adipokine - CTRP-6 - overweight/obesity - Insulin resistance
