CC BY-NC-ND 4.0 · Endosc Int Open 2019; 07(10): E1262-E1275
DOI: 10.1055/a-0958-2183
Review
Owner and Copyright © Georg Thieme Verlag KG 2019

The role of EUS in diagnosis and treatment of liver disorders

Sara Campos
1   Department of Gastroenterology, Hospital Garcia da Orta, Portugal
2   Department of Gastroenterology and Hepatology, Erasmus MC, The Netherlands
,
Jan-Werner Poley
2   Department of Gastroenterology and Hepatology, Erasmus MC, The Netherlands
,
Lydi van Driel
2   Department of Gastroenterology and Hepatology, Erasmus MC, The Netherlands
,
Marco J. Bruno
2   Department of Gastroenterology and Hepatology, Erasmus MC, The Netherlands
› Institutsangaben
Weitere Informationen

Publikationsverlauf

submitted 04. Oktober 2018

accepted after revision 07. Januar 2019

Publikationsdatum:
01. Oktober 2019 (online)

Abstract

Background and aim Transabdominal ultrasound (US), computed tomographic scanning (CT) and magnetic resonance imaging (MRI) are established diagnostic tools for liver diseases. Percutaneous transhepatic cholangiography is used to perform hepatic interventional procedures including biopsy, biliary drainage procedures, and radiofrequency ablation. Despite their widespread use, these techniques have limitations. Endoscopic ultrasound (EUS), a tool that has proven useful for evaluating the mediastinum, esophagus, stomach, pancreas, and biliary tract, has an expanding role in the field of hepatology complementing the traditional investigational modalities. This review aimed to assess the current scientific evidence regarding diagnostic and therapeutic applications of EUS for hepatic diseases.

 
  • References

  • 1 Couinaud C. [Liver lobes and segments: notes on the anatomical architecture and surgery of the liver ]. Presse Med 1954; 62: 709-712
  • 2 Bhatia V, Hijioka S, Hara K. et al. Endoscopic ultrasound description of liver segmentation and anatomy: Endoscopic ultrasound anatomy of liver. Dig Endosc 2014; 26: 482-490
  • 3 Andanappa HK, Dai Q, Korimilli A. et al. Acoustic liver biopsy using endoscopic ultrasound. Dig Dis Sci 2008; 53: 1078-1083
  • 4 Singh P, Mukhopadhyay P, Bhatt B. et al. Endoscopic ultrasound versus CT scan for detection of the metastases to the liver: results of a prospective comparative study. J Clin Gastroenterol 2009; 43: 367-373
  • 5 Caletti G, Brocchi E, Baraldini M. et al. Assessment of portal hypertension by endoscopic ultrasonography. Gastrointest Endosc 1990; 36: S21-S27
  • 6 Seicean A. Endoscopic ultrasound in the diagnosis and treatment of upper digestive bleeding: a useful tool. J Gastrointest Liver Dis JGLD 2013; 22: 465-469
  • 7 Wiechowska-Kozłowska A, Zasada K, Milkiewicz M. et al. Correlation between endosonographic and doppler ultrasound features of portal hypertension in patients with cirrhosis. Gastroenterol Res Pract 2012; 2012: 1-5
  • 8 Wiechowska-Kozlowska A, Raszeja-Wyszomirska J, Wasilewicz MP. et al. Upper gastrointestinal endosonography in patients evaluated for liver transplantation. Transplant Proc 2009; 41: 3082-3084
  • 9 Hsieh J-S, Wang W-M, Perng D-S. et al. Modified devascularization surgery for isolated gastric varices assessed by endoscopic ultrasonography. Surg Endosc 2004; 18: 666-671
  • 10 Schiano TD, Adrain AL, Cassidy MJ. et al. Use of high-resolution endoluminal sonography to measure the radius and wall thickness of esophageal varices. Gastrointest Endosc 1996; 44: 425-428
  • 11 Jacobson BC. Pressed for an answer: has elastography finally come to EUS?. Gastrointest Endosc 2007; 66: 301-303
  • 12 Claudon M, Dietrich C, Choi B. et al. Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) in the liver – update 2012. Ultraschall Med - Eur J Ultrasound 2012; 34: 11-29
  • 13 Hollerbach S, Reiser M, Topalidis T. et al. Diagnosis of hepatocellular carcinoma (hcc) in a high-risk patient by using transgastric EUS-guided fine-needle biopsy (EUS-FNA). Z Für Gastroenterol 2003; 41: 995-998
  • 14 Choudhary N, Bansal R, Puri R. et al. Impact and safety of endoscopic ultrasound guided fine needle aspiration on patients with cirrhosis and pyrexia of unknown origin in India. Endosc Int Open 2016; 04: E953-E956
  • 15 Dumonceau J-M, Deprez P, Jenssen C. et al. Indications, results, and clinical impact of endoscopic ultrasound (EUS)-guided sampling in gastroenterology: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline – Updated January 2017. Endoscopy 2017; 49: 695-714
  • 16 Pineda JJ, Diehl DL, Miao CL. et al. EUS-guided liver biopsy provides diagnostic samples comparable with those via the percutaneous or transjugular route. Gastrointest Endosc 2016; 83: 360-365
  • 17 Lee WJ, Uradomo LT, Zhang Y. et al. Comparison of the Diagnostic yield of EUS needles for liver biopsy: ex vivo study. Diagn Ther Endosc 2017; 2017: 1-5
  • 18 Prasad P, Schmulewitz N, Patel A. et al. Detection of occult liver metastases during EUS for staging of malignancies. Gastrointest Endosc 2004; 59: 49-53
  • 19 McGrath K, Brody D, Luketich J. et al. Detection of unsuspected left hepatic lobe metastases during EUS staging of cancer of the esophagus and cardia. Am J Gastroenterol 2006; 101: 1742-1746
  • 20 Awad SS, Fagan S, Abudayyeh S. et al. Preoperative evaluation of hepatic lesions for the staging of hepatocellular and metastatic liver carcinoma using endoscopic ultrasonography. Am J Surg 2002; 184: 601-604 ; discussion 604-605
  • 21 Singh P, Erickson RA, Mukhopadhyay P. et al. EUS for detection of the hepatocellular carcinoma: results of a prospective study. Gastrointest Endosc 2007; 66: 265-273
  • 22 Nguyen P, Feng JC, Chang KJ. Endoscopic ultrasound (EUS) and EUS-guided fine-needle aspiration (FNA) of liver lesions. Gastrointest Endosc 1999; 50: 357-361
  • 23 Fujii-Lau LL, Abu Dayyeh BK, Bruno MJ. et al. EUS-derived criteria for distinguishing benign from malignant metastatic solid hepatic masses. Gastrointest Endosc 2015; 81: 1188-1196.e7
  • 24 Nadan R, Irena H, Milorad O. et al. EUS elastography in the diagnosis of focal liver lesions. Gastrointest Endosc 2007; 66: 823-824
  • 25 Sandulescu L, Padureanu V, Dumitrescu C. et al. A pilot study of real time elastography in the differentiation of focal liver lesions. Curr Health Sci J 2012; 38: 32-35
  • 26 D’Onofrio M, Crosara S, De Robertis R. et al. Contrast-Enhanced Ultrasound of Focal Liver Lesions. Am J Roentgenol 2015; 205: W56-W66
  • 27 Minaga K, Takenaka M, Kitano M. et al. 115 Improved diagnosis of liver metastases using kupffer-phase image of contrast-enhanced harmonic endoscopic ultrasonography in patients with pancreatic cancer. Gastrointest Endosc 2017; 85: AB53
  • 28 Xu H-X. Contrast-enhanced ultrasound: The evolving applications. World J Radiol 2009; 1: 15
  • 29 Liu M, Lin M, Lu M. et al. Comparison of contrast-enhanced ultrasound and contrast-enhanced computed tomography in evaluating the treatment response to transcatheter arterial chemoembolization of hepatocellular carcinoma using modified RECIST. Eur Radiol 2015; 25: 2502-2511
  • 30 Nakaji S, Hirata N. Evaluation of the viability of hepatocellular carcinoma in the caudate lobe using contrast-enhanced endoscopic ultrasonography after transarterial chemoembolization. Endosc Ultrasound 2016; 5: 390
  • 31 DeWitt J. Endoscopic ultrasound–guided fine needle aspiration cytology of solid liver lesions: a large single-center experience. Am J Gastroenterol 2003; 98: 1976-1981
  • 32 Crowe DR, Eloubeidi MA, Chhieng DC. et al. Fine-needle aspiration biopsy of hepatic lesions: Computerized tomographic-guided versus endoscopic ultrasound-guided FNA. Cancer 2006; 108: 180-185
  • 33 Hollerbach S, Willert J, Topalidis T. et al. Endoscopic ultrasound-guided fine-needle aspiration biopsy of liver lesions: histological and cytological assessment. Endoscopy 2003; 35: 743-749
  • 34 Anand D, Barroeta JE, Gupta PK. et al. Endoscopic ultrasound guided fine needle aspiration of non-pancreatic lesions: an institutional experience. J Clin Pathol 2007; 60: 1254-1262
  • 35 Crowe A, Knight CS, Jhala D. et al. Diagnosis of metastatic fibrolamellar hepatocellular carcinoma by endoscopic ultrasound guided fine needle aspiration. CytoJournal [Internet] 2011; 8: 2
  • 36 Kawakami H, Kuwatani M, Sakamoto N. Hepatobiliary alveolar echinococcosis infiltration of the hepatic hilum diagnosed by endoscopic ultrasonography-guided fine-needle aspiration. Dig Endosc 2013; 25: 339-340
  • 37 Lee YN, Moon JH, Kim HK. et al. Usefulness of endoscopic ultrasound-guided sampling using core biopsy needle as a percutaneous biopsy rescue for diagnosis of solid liver mass: Combined histological-cytological analysis: EUS-guided biopsy for solid liver mass. J Gastroenterol Hepatol 2015; 30: 1161-1166
  • 38 Reyes MCD, Huang X, Bain A. et al. Primary pancreatic leiomyosarcoma with metastasis to the liver diagnosed by endoscopic ultrasound-guided fine needle aspiration and fine needle biopsy: A case report and review of literature. Diagn Cytopathol 2016; 44: 1070-1073
  • 39 Peng HQ, Darwin P, Papadimitriou JC. et al. Liver metastases of pancreatic acinar cell carcinoma with marked nuclear atypia and pleomorphism diagnosed by EUS FNA cytology: a case report with emphasis on FNA cytological findings. CytoJournal 2006; 3: 29
  • 40 Schulman AR, Thompson CC, Odze R. et al. Optimizing EUS-guided liver biopsy sampling: comprehensive assessment of needle types and tissue acquisition techniques. Gastrointest Endosc 2017; 85: 419-426
  • 41 Lopes C, de Garcia R, Santos G. et al. Gastric compression due to a cystic liver metastasis of vulvar carcinoma diagnosed by endoscopic ultrasound-guided fine-needle aspiration. Endoscopy 2014; 46: E208-E209
  • 42 Yang D, Zhu H, DiMaio CJ. Abdominal Splenosis mimicking a liver mass: diagnosis by EUS-FNA. Clin Gastroenterol Hepatol 2016; 14: e16-e17
  • 43 Husney J, Guttmann S, Anyadike N. et al. Endoscopic ultrasound-fine needle aspiration: A novel way to diagnose a solitary extramedullary plasmacytoma of the liver. Endosc Ultrasound 2016; 5: 134
  • 44 Oh D, Seo D-W, Hong S-M. et al. Endoscopic ultrasound-guided fine-needle aspiration can target right liver mass. Endosc Ultrasound 2017; 6: 109
  • 45 tenBerge J, Hoffman BJ, Hawes RH. et al. EUS-guided fine needle aspiration of the liver: Indications, yield, and safety based on an international survey of 167 cases. Gastrointest Endosc 2002; 55: 859-862
  • 46 Prachayakul V, Aswakul P, Kachintorn U. EUS guided fine needle aspiration cytology of liver nodules suspicious for malignancy: yields, complications and impact on management. J Med Assoc Thail Chotmaihet Thangphaet 2012; 95: S56-S60
  • 47 Bogstad J, Vilmann P, Burcharth F. Early detection of recurrent hepatocellular carcinoma by endosonographically guided fine-needle aspiration biopsy. Endoscopy 1997; 29: 322-324
  • 48 Goel RK, Jha B, Mohapatra I. et al. A liver mass in a case of gastrointestinal stromal tumour of the stomach is not always a metastasis. Cytopathology 2016; 27: 74-76
  • 49 Choi HJ, Moon JH, Kim HK. et al. KRAS mutation analysis by next-generation sequencing in endoscopic ultrasound-guided sampling for solid liver masses: KRAS mutation analysis in EUS sampling. J Gastroenterol Hepatol 2017; 32: 154-162
  • 50 Suzuki R, Shin D, Richards-Kortum R. et al. In vivo cytological observation of liver and spleen by using high-resolution microendoscopy system under endoscopic ultrasound guidance: A preliminary study using a swine model. Endosc Ultrasound 2016; 5: 239
  • 51 Kayar Y, Turkdogan KA, Baysal B. et al. EUS-guided FNA of a portal vein thrombus in hepatocellular carcinoma. Pan Afr Med J 2015; 21: 86
  • 52 Lai R, Stephens V, Bardales R. Diagnosis and staging of hepatocellular carcinoma by EUS-FNA of a portal vein thrombus. Gastrointest Endosc 2004; 59: 574-577
  • 53 Storch I, Gomez C, Contreras F. et al. hepatocellular carcinoma (HCC) with portal vein invasion, masquerading as pancreatic mass, diagnosed by endoscopic ultrasound-guided fine needle aspiration (EUS-FNA). Dig Dis Sci 2007; 52: 789-791
  • 54 Moreno M, Gimeno-García A, Corriente M. et al. EUS-FNA of a portal vein thrombosis in a patient with a hidden hepatocellular carcinoma: confirmation technique after contrast-enhanced ultrasound. Endoscopy 2014; 46: E590-E591
  • 55 Michael H, Lenza C, Gupta M. et al. Endoscopic ultrasound -guided fine-needle aspiration of a portal vein thrombus to aid in the diagnosis and staging of hepatocellular carcinoma. Gastroenterol Hepatol 2011; 7: 124-129
  • 56 European Association For The Study Of The Liver. European Organisation For Research And Treatment Of Cancer. EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol 2012; 56: 908-943
  • 57 Delconte G, Bhoori S, Milione M. et al. Endoscopic ultrasound-guided fine needle aspiration of splenic vein thrombosis: a novel approach to the portal venous system. Endoscopy 2016; 48: E40-E41
  • 58 Wang K-X, Ben Q-W, Jin Z-D. et al. Assessment of morbidity and mortality associated with EUS-guided FNA: a systematic review. Gastrointest Endosc 2011; 73: 283-290
  • 59 Hara K, Bhatia V, Hijioka S. et al. A convex EUS is useful to diagnose vascular invasion of cancer, especially hepatic hilus cancer: a convex EUS is useful to diagnose. Dig Endosc 2011; 23: 26-28
  • 60 EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. J Hepatol 2015; 63: 237-264
  • 61 Rimbaş M, Gheonea DI, Săndulescu L. et al. EUS elastography in evaluating chronic liver disease. Why not from Inside?. Curr Health Sci J 2009; 35: 225-227
  • 62 Diehl D, Johal A, Khara H. et al. Endoscopic ultrasound-guided liver biopsy: a multicenter experience. Endosc Int Open 2015; 3: E210-E215
  • 63 Stavropoulos SN, Im GY, Jlayer Z. et al. High yield of same-session EUS-guided liver biopsy by 19-gauge FNA needle in patients undergoing EUS to exclude biliary obstruction. Gastrointest Endosc 2012; 75: 310-318
  • 64 Lutz H, Wasmuth H, Streetz K. et al. Endoscopic ultrasound as an early diagnostic tool for primary sclerosing cholangitis: a prospective pilot study. Endoscopy 2012; 44: 934-939
  • 65 DeWitt J, McGreevy K, Cummings O. et al. Initial experience with EUS-guided Tru-cut biopsy of benign liver disease. Gastrointest Endosc 2009; 69: 535-542
  • 66 Mathew A. EUS-guided routine liver biopsy in selected patients. Am J Gastroenterol 2007; 102: 2354-2355
  • 67 Gleeson FC, Clayton AC, Zhang L. et al. Adequacy of endoscopic ultrasound core needle biopsy specimen of nonmalignant hepatic parenchymal disease. Clin Gastroenterol Hepatol 2008; 6: 1437-1440
  • 68 Nakai Y, Samarasena J, Iwashita T. et al. Autoimmune hepatitis diagnosed by endoscopic ultrasound-guided liver biopsy using a new 19-gauge histology needle. Endoscopy 2012; 44: E67-E68
  • 69 Gor N, Salem SB, Jakate S. et al. Histological adequacy of EUS-guided liver biopsy when using a 19-gauge non–Tru-Cut FNA needle. Gastrointest Endosc 2014; 79: 170-172
  • 70 Sey MSL, Al-Haddad M, Imperiale TF. et al. EUS-guided liver biopsy for parenchymal disease: a comparison of diagnostic yield between two core biopsy needles. Gastrointest Endosc 2016; 83: 347-352
  • 71 Johal A, Khara H, Maksimak M. et al. Endoscopic ultrasound-guided liver biopsy in pediatric patients. Endosc Ultrasound 2014; 3: 191
  • 72 Saab S, Phan J, Jimenez MA. et al. Endoscopic ultrasound liver biopsies accurately predict the presence of fibrosis in patients with fatty liver. Clin Gastroenterol Hepatol 2017; 15: 1477-1478
  • 73 Shah ND, Sasatomi E, Baron TH. Endoscopic ultrasound-guided parenchymal liver biopsy: single center experience of a new dedicated core needle. Clin Gastroenterol Hepatol 2017; 15: 784-786
  • 74 Nieto J, Khaleel H, Challita Y. et al. EUS-guided fine-needle core liver biopsy sampling using a novel 19-gauge needle with modified 1-pass, 1 actuation wet suction technique. Gastrointest Endosc 2018; 87: 469-475
  • 75 Shahshahan M, Gertz H, Fakhreddine AY. et al. Mo1285 endoscopic ultrasound-guided liver biopsy versus percutaneous and trans-jugular liver biopsy for evaluation of liver parenchyma. Gastrointest Endosc 2017; 85: AB490
  • 76 Hassan G, Sahai A, Paquin S. Near-fatal hemorrhagic shock after endoscopic ultrasound-guided liver biopsy. Endoscopy 2015; 47: E378-E388
  • 77 Choudhuri G, Dhiman RK, Agarwal DK. Endosonographic evaluation of the venous anatomy around the gastro-esophageal junction in patients with portal hypertension. Hepatogastroenterology 1996; 43: 1250-1255
  • 78 Lee YT, Chan FKL, Ching JYL. et al. Diagnosis of Gastroesophageal Varices and Portal Collateral Venous Abnormalities by Endosonography in Cirrhotic Patients. Endoscopy 2002; 34: 391-8
  • 79 McKiernan PJ, Sharif K, Gupte GL. The role of endoscopic ultrasound for evaluating portal hypertension in children being assessed for intestinal transplantation. Transplantation 2008; 86: 1470-1473
  • 80 Konishi Y, Nakamura T, Kida H. et al. Catheter US probe EUS evaluation of gastric cardia and perigastric vascular structures to predict esophageal variceal recurrence. Gastrointest Endosc 2002; 55: 197-203
  • 81 Miller LS, Schiano TD, Adrain A. et al. Comparison of high-resolution endoluminal sonography to video endoscopy in the detection and evaluation of esophageal varices. Hepatology 1996; 24: 552-555
  • 82 Burtin P, Calès P, Oberti F. et al. Endoscopic ultrasonographic signs of portal hypertension in cirrhosis. Gastrointest Endosc 1996; 44: 257-261
  • 83 Lo GH, Lai KH, Cheng JS. et al. Prevalence of paraesophageal varices and gastric varices in patients achieving variceal obliteration by banding ligation and by injection sclerotherapy. Gastrointest Endosc 1999; 49: 428-436
  • 84 Pontes JM, Leitão MC, Portela FA. et al. Endoscopic ultrasonography in the treatment of oesophageal varices by endoscopic sclerotherapy and band ligation: do we need it?. Eur J Gastroenterol Hepatol 1995; 7: 41-46
  • 85 Sgouros SN, Bergele C, Avgerinos A. Endoscopic ultrasonography in the diagnosis and management of portal hypertension. Where are we next?. Dig Liver Dis 2006; 38: 289-295
  • 86 Curcio G. Case of obscure-overt gastrointestinal bleeding after pediatric liver transplantation explained by endoscopic ultrasound. World J Gastrointest Endosc 2012; 4: 571
  • 87 Rana S, Bhasin D, Chaudhary V. et al. Clinical, endoscopic and endoscopic ultrasound features of duodenal varices: A report of 10 cases. Endosc Ultrasound 2014; 3: 54
  • 88 Rana SS. Sample Organization. Communication of duodenal varix with pericholedochal venous plexus demonstrated by endoscopic ultrasound in a patient of portal biliopathy. Endosopic Ultrasound 2012; 1: 165
  • 89 Rana SS, Bhasin DK, Singh K. Duodenal varix diagnosed by endoscopic ultrasound. Clin Gastroenterol Hepatol 2010; 8: A24
  • 90 Sharma M, Mohan P, Rameshbabu CS. et al. Identification of perforators in patients with duodenal varices by endoscopic ultrasound—a case series [with video]. J Clin Exp Hepatol 2012; 2: 229-237
  • 91 Liu JB, Miller LS, Feld RI. et al. Gastric and esophageal varices: 20-MHz transnasal endoluminal US. Radiology 1993; 187: 363-366
  • 92 Nishizono M, Haraguchi Y, Eto T. et al. Endoscopic ultrasonography using a 15/20 MHz probe in a direct contact technique: evaluation and application in esophageal and gastric varices. Fukuoka Igaku Zasshi Hukuoka Acta Medica 1994; 85: 251-255
  • 93 Suzuki T, Matsutani S, Umebara K. et al. EUS changes predictive for recurrence of esophageal varices in patients treated by combined endoscopic ligation and sclerotherapy. Gastrointest Endosc 2000; 52: 611-617
  • 94 Nakamura H, Endo M, Shimojuu K. et al. Esophageal varices evaluated by endoscopic ultrasonography: observation of collateral circulation during non-shunting operations. Surg Endosc 1990; 4: 69-74 ; discussion 75
  • 95 Caletti GC, Brocchi E, Ferrari A. et al. Value of endoscopic ultrasonography in the management of portal hypertension. Endoscopy 1992; 24: 342-346
  • 96 Avunduk C, Hampf F. Endoscopic ultrasound in the diagnosis of watermelon stomach. J Clin Gastroenterol 1996; 22: 104-106
  • 97 Parente F, Petrillo M, Vago L. et al. The watermelon stomach: clinical, endoscopic, endosonographic, and therapeutic aspects in three cases. Endoscopy 1995; 27: 203-206
  • 98 Chen TK, Wu CH, Lee CL. et al. Endoscopic ultrasonography in the differential diagnosis of giant gastric folds. J Formos Med Assoc Taiwan Yi Zhi 1999; 98: 261-264
  • 99 Wong RCK, Farooq FT, Chak A. Endoscopic Doppler US probe for the diagnosis of gastric varices (with videos). Gastrointest Endosc 2007; 65: 491-496
  • 100 Giday SA, Clarke JO, Buscaglia JM. et al. EUS-guided portal vein catheterization: a promising novel approach for portal angiography and portal vein pressure measurements. Gastrointest Endosc 2008; 67: 338-342
  • 101 Lai L, Poneros J, Santilli J. et al. EUS-guided portal vein catheterization and pressure measurement in an animal model: a pilot study of feasibility. Gastrointest Endosc 2004; 59: 280-283
  • 102 Giday SA, Ko C-W, Clarke JO. et al. EUS-guided portal vein carbon dioxide angiography: a pilot study in a porcine model. Gastrointest Endosc 2007; 66: 814-819
  • 103 Schulman AR, Thompson CC, Ryou M. EUS-guided portal pressure measurement using a digital pressure wire with real-time remote display: a novel, minimally invasive technique for direct measurement in an animal model. Gastrointest Endosc 2016; 83: 817-820
  • 104 Schulman AR, Thompson CC, Ryou M. Endoscopic ultrasound-guided direct portal pressure measurement using a digital pressure wire with real-time remote display: a survival study. J Laparoendosc Adv Surg Tech A 2017; 27: 1051-1054
  • 105 Magno P, Ko C-W, Buscaglia JM. et al. EUS-guided angiography: a novel approach to diagnostic and therapeutic interventions in the vascular system. Gastrointest Endosc 2007; 66: 587-591
  • 106 Fujii-Lau L, Leise M, Kamath P. et al. Endoscopic ultrasound-guided portal-systemic pressure gradient measurement. Endoscopy 2014; 46: E654-E656
  • 107 Huang JY, Samarasena JB, Tsujino T. et al. EUS-guided portal pressure gradient measurement with a simple novel device: a human pilot study. Gastrointest Endosc 2017; 85: 996-1001
  • 108 Jackson FW, Adrain AL, Black M. et al. Calculation of esophageal variceal wall tension by direct sonographic and manometric measurements. Gastrointest Endosc 1999; 50: 247-251
  • 109 Miller ES, Kim JK, Gandehok J. et al. A new device for measuring esophageal variceal pressure. Gastrointest Endosc 2002; 56: 284-291
  • 110 Miller LS, Dai Q, Thomas A. et al. A new ultrasound-guided esophageal variceal pressure-measuring device. Am J Gastroenterol 2004; 99: 1267-1273
  • 111 Pontes JM, Leitão MC, Portela F. et al. Endosonographic Doppler-guided manometry of esophageal varices: experimental validation and clinical feasibility. Endoscopy 2002; 34: 966-972
  • 112 Schiano TD, Adrain AL, Vega KJ. et al. High-resolution endoluminal sonography assessment of the hematocystic spots of esophageal varices. Gastrointest Endosc 1999; 49: 424-427
  • 113 Miller L, Banson FL, Bazir K. et al. Risk of esophageal variceal bleeding based on endoscopic ultrasound evaluation of the sum of esophageal variceal cross-sectional surface area. Am J Gastroenterol 2003; 98: 454-459
  • 114 Sato T, Yamazaki K, Toyota J. et al. Observation of Gastric Variceal Flow characteristics by endoscopic ultrasonography using color Doppler. Am J Gastroenterol 2008; 103: 575-580
  • 115 Irisawa A, Saito A, Obara K. et al. Endoscopic recurrence of esophageal varices is associated with the specific EUS abnormalities: Severe periesophageal collateral veins and large perforating veins. Gastrointest Endosc 2001; 53: 77-84
  • 116 Faigel DO, Rosen HR, Sasaki A. et al. EUS in cirrhotic patients with and without prior variceal hemorrhage in comparison with noncirrhotic control subjects. Gastrointest Endosc 2000; 52: 455-462
  • 117 Irisawa A, Obara K, Sato Y. et al. EUS analysis of collateral veins inside and outside the esophageal wall in portal hypertension. Gastrointest Endosc 1999; 50: 374-380
  • 118 Men C, Zhang G. Endoscopic ultrasonography predicts early esophageal variceal bleeding in liver cirrhosis: A case report. Medicine (Baltimore) 2017; 96: e6749
  • 119 Kume K, Yamasaki M, Watanabe T. et al. Mild collateral varices and a fundic plexus without perforating veins on EUS predict endoscopic non-recurrence of esophageal varices after EVL. Hepatogastroenterology 2011; 58: 798-801
  • 120 Masalaite L, Valantinas J, Stanaitis J. The role of collateral veins detected by endosonography in predicting the recurrence of esophageal varices after endoscopic treatment: a systematic review. Hepatol Int 2014; 8: 339-351
  • 121 Seno H, Konishi Y, Wada M. et al. Improvement of collateral vessels in the vicinity of gastric cardia after endoscopic variceal ligation therapy for esophageal varices. Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc 2004; 2: 400-404
  • 122 Sato T, Yamazaki K, Toyota J. et al. Perforating veins in recurrent esophageal varices evaluated by endoscopic color Doppler ultrasonography with a galactose-based contrast agent. J Gastroenterol 2004; 39: 422-428
  • 123 Sato T, Yamazaki K, Toyota J. et al. Endoscopic ultrasonographic evaluation of hemodynamics related to variceal relapse in esophageal variceal patients. Hepatol Res 2009; 39: 126-133
  • 124 Masalaite L, Valantinas J, Stanaitis J. Endoscopic ultrasound findings predict the recurrence of esophageal varices after endoscopic band ligation: a prospective cohort study. Scand J Gastroenterol 2015; 50: 1322-1330
  • 125 Leung VK, Sung JJ, Ahuja AT. et al. Large paraesophageal varices on endosonography predict recurrence of esophageal varices and rebleeding. Gastroenterology 1997; 112: 1811-1816
  • 126 Irisawa A, Obara K, Bhutani MS. et al. Role of para-esophageal collateral veins in patients with portal hypertension based on the results of endoscopic ultrasonography and liver scintigraphy analysis. J Gastroenterol Hepatol 2003; 18: 309-314
  • 127 Carneiro FOAA, Retes FA, Matuguma SE. et al. Role of EUS evaluation after endoscopic eradication of esophageal varices with band ligation. Gastrointest Endosc 2016; 84: 400-407
  • 128 Dhiman RK, Choudhuri G, Saraswat VA. et al. Role of paraoesophageal collaterals and perforating veins on outcome of endoscopic sclerotherapy for oesophageal varices: an endosonographic study. Gut 1996; 38: 759-764
  • 129 Elsamman MK, Fujiwara Y, Kameda N. et al. Predictive factors of worsening of esophageal varices after balloon-occluded retrograde transvenous obliteration in patients with gastric varices. Am J Gastroenterol 2009; 104: 2214-2221
  • 130 Kuramochi A, Imazu H, Kakutani H. et al. Color Doppler endoscopic ultrasonography in identifying groups at a high-risk of recurrence of esophageal varices after endoscopic treatment. J Gastroenterol 2007; 42: 219-224
  • 131 Hino S, Kakutani H, Ikeda K. et al. Hemodynamic analysis of esophageal varices using color Doppler endoscopic ultrasonography to predict recurrence after endoscopic treatment. Endoscopy 2001; 33: 869-872
  • 132 Liao W-C, Chen P-H, Hou M-C. et al. Endoscopic ultrasonography assessment of para-esophageal varices predicts efficacy of propranolol in preventing recurrence of esophageal varices. J Gastroenterol 2015; 50: 342-349
  • 133 Escorsell A, Bordas JM, Feu F. et al. Endoscopic assessment of variceal volume and wall tension in cirrhotic patients: effects of pharmacological therapy. Gastroenterology 1997; 113: 1640-1646
  • 134 Lee YT, Sung JJ, Yung MY. et al. Use of color Doppler EUS in assessing azygos blood flow for patients with portal hypertension. Gastrointest Endosc 1999; 50: 47-52
  • 135 Nishida H, Giostra E, Spahr L. et al. Validation of color Doppler EUS for azygos blood flow measurement in patients with cirrhosis: Application to the acute hemodynamic effects of somatostatin, octreotide, or placebo. Gastrointest Endosc 2001; 54: 24-30
  • 136 Hansen EF, Bendtsen F, Brinc K. Endoscopic Doppler ultrasound for measurement of azygos blood flow: validation against thermodilution and assessment of pharmacological effects of terlipressin in portal hypertension. scand j gastroenterol 2001; 36: 318-325
  • 137 McDermott S, Gervais D. Radiofrequency ablation of liver tumors. Semin Interv Radiol 2013; 30: 049-055
  • 138 Varadarajulu S, Jhala NC, Drelichman ER. EUS-guided radiofrequency ablation with a prototype electrode array system in an animal model (with video). Gastrointest Endosc 2009; 70: 372-376
  • 139 Yoon WJ, Daglilar ES, Kamionek M. et al. Evaluation of radiofrequency ablation using a 1-Fr wire electrode in porcine pancreas, liver, gallbladder, spleen, kidney, stomach, and lymph nodes: A pilot study: RFA of abdominal organs. Dig Endosc 2016; 28: 465-468
  • 140 Rustagi T, Gleeson FC, Abu Dayyeh BK. et al. Evaluation of Effects of Radiofrequency Ablation of Ex vivo Liver Using the 1-Fr Wire Electrode. J Clin Gastroenterol 2018; 52: 168-171
  • 141 Hines-Peralta A, Hollander CY, Solazzo S. et al. Hybrid radiofrequency and cryoablation device: preliminary results in an animal model. J Vasc Interv Radiol 2004; 15: 1111-1120
  • 142 Carrara S, Arcidiacono P, Albarello L. et al. Endoscopic ultrasound-guided application of a new internally gas-cooled radiofrequency ablation probe in the liver and spleen of an animal model: a preliminary study. Endoscopy 2008; 40: 759-763
  • 143 Di Matteo F, Grasso R, Pacella CM. et al. EUS-guided Nd:YAG laser ablation of a hepatocellular carcinoma in the caudate lobe. Gastrointest Endosc 2011; 73: 632-636
  • 144 Jiang T, Tian G, Bao H. et al. EUS dating with laser ablation against the caudate lobe or left liver tumors: a win-win proposition?. Cancer Biol Ther 2018; 19: 145-152
  • 145 Pioche M, Lafon C, Constanciel E. et al. High-intensity focused ultrasound liver destruction through the gastric wall under endoscopic ultrasound control: first experience in living pigs. Endoscopy 2012; 44: E376-E377
  • 146 Li T, Khokhlova T, Maloney E. et al. Endoscopic high-intensity focused US: technical aspects and studies in an in vivo porcine model (with video). Gastrointest Endosc 2015; 81: 1243-1250
  • 147 Nakaji S, Hirata N, Mikata R. et al. Clinical outcomes of endoscopic ultrasound-guided ethanol injection for hepatocellular carcinoma in the caudate lobe. Endosc Int Open 2016; 04: E111-E115
  • 148 DiMaio CJ. Sp616 EUS-guided ethanol ablation for management of metastatic hepatocellular carcinoma. Gastrointest Endosc 2013; 77: AB115
  • 149 Nakaji S, Hirata N, Iwaki K. et al. Endoscopic ultrasound (EUS)-guided ethanol injection for hepatocellular carcinoma difficult to treat with percutaneous local treatment. Endoscopy 2012; 44: E380-E380
  • 150 Jiang T, Deng Z, Tian G. et al. Efficacy and safety of endoscopic ultrasonography-guided interventional treatment for refractory malignant left-sided liver tumors: a case series of 26 patients. Sci Rep 2015; 6: 36098
  • 151 Hu Y-H, Tuo X-P, Jin Z-D. et al. Endoscopic ultrasound (EUS)-guided ethanol injection in hepatic metastatic carcinoma: a case report. Endoscopy 2010; 42: E256-E257
  • 152 Barclay RL, Perez-Miranda M, Giovannini M. EUS-guided treatment of a solid hepatic metastasis. Gastrointest Endosc 2002; 55: 266-270
  • 153 Faigel D, Lake D, Landreth T. et al. Endoscopic ultrasonography-guided portal injection chemotherapy for hepatic metastases. Endosc Ultrasound 2014; 3: S1
  • 154 Choi J-H, Seo D-W, Park DH. et al. Fiducial placement for stereotactic body radiation therapy under only endoscopic ultrasonography guidance in pancreatic and hepatic malignancy: practical feasibility and safety. Gut Liver 2014; 8: 88-93
  • 155 Dhadham G, Hoffe S, Harris C. et al. Endoscopic ultrasound-guided fiducial marker placement for image-guided radiation therapy without fluoroscopy: safety and technical feasibility. Endosc Int Open 2016; 04: E378-E382
  • 156 Hemming AW, Reed AI, Howard RJ. et al. Preoperative portal vein embolization for extended hepatectomy. Ann Surg 2003; 237: 686-693
  • 157 Liu H, Fu Y. Portal vein embolization before major hepatectomy. World J Gastroenterol 2005; 11: 2051-2054
  • 158 Matthes K, Sahani D, Holalkere NS. et al. Feasibility of endoscopic ultrasound-guided portal vein embolization with Enteryx. Acta Gastro-Enterol Belg 2005; 68: 412-415
  • 159 Lee S, Seo D-W, Paik WH. et al. Ethanol lavage of huge hepatic cysts by using EUS guidance and a percutaneous approach. Gastrointest Endosc 2014; 80: 1014-1021
  • 160 Shi G, Sun S, Li H. et al. A case of a giant cyst in the left lobe of the liver successfully treated with endoscopic ultrasound-guided fine needle aspiration (with video). Endosc Ultrasound 2017; 6: 343-346
  • 161 Cai Y-L, Xiong X-Z, Lu J. et al. Percutaneous needle aspiration versus catheter drainage in the management of liver abscess: a systematic review and meta-analysis. HPB 2015; 17: 195-201
  • 162 Bertel CK, van Heerden JA, Sheedy PF. Treatment of pyogenic hepatic abscesses. Surgical vs percutaneous drainage. Arch Surg Chic Ill 1960 1986; 121: 554-558
  • 163 Seewald S, Imazu H, Omar S. et al. EUS-guided drainage of hepatic abscess. Gastrointest Endosc 2005; 61: 495-498
  • 164 Ang T, Seewald S, Teo E. et al. EUS-guided drainage of ruptured liver abscess. Endoscopy 2009; 41: E21-E22
  • 165 Noh SH, Park DH, Kim YR. et al. EUS-guided drainage of hepatic abscesses not accessible to percutaneous drainage (with videos). Gastrointest Endosc 2010; 71: 1314-1319
  • 166 Itoi T, Ang TL, Seewald S. et al. Endoscopic ultrasonography-guided drainage for tuberculous liver abscess drainage: EUS-guided liver abscess drainage. Dig Endosc 2011; 23: 158-161
  • 167 Keohane J, Dimaio CJ, Schattner MA. et al. EUS-guided transgastric drainage of caudate lobe liver abscesses. J Interv Gastroenterol 2011; 1: 139-141
  • 168 Medrado B, Carneiro F, Vilaça T. et al. Endoscopic ultrasound-guided drainage of giant liver abscess associated with transgastric migration of a self-expandable metallic stent. Endoscopy 2013; 45: E331-E332
  • 169 Alcaide N, Vargas-Garcia AL, de la Serna-Higuera C. et al. EUS-guided drainage of liver abscess by using a lumen-apposing metal stent (with video). Gastrointest Endosc 2013; 78: 941-942
  • 170 Kawakami H, Kawakubo K, Kuwatani M. et al. Endoscopic ultrasonography-guided liver abscess drainage using a dedicated, wide, fully covered self-expandable metallic stent with flared-ends. Endoscopy 2014; 46: E982-E983
  • 171 Tonozuka R, Itoi T, Tsuchiya T. et al. EUS-guided drainage of hepatic abscess and infected biloma using short and long metal stents (with videos). Gastrointest Endosc 2015; 81: 1463-1469
  • 172 Ogura T, Masuda D, Saori O. et al. Clinical outcome of endoscopic ultrasound-guided liver abscess drainage using self-expandable covered metallic stent (with video). Dig Dis Sci 2016; 61: 303-308
  • 173 Koizumi K, Masuda S, Uojima H. et al. Endoscopic ultrasound-guided drainage of an amoebic liver abscess extending into the hepatic subcapsular space. Clin J Gastroenterol 2015; 8: 232-235
  • 174 Kumta NA, Torres-Ruiz F, Reinoso PJ. et al. Endoscopic management of hepatic abscess after EUS-guided hepaticogastrostomy. Gastrointest Endosc 2016; 84: 1054-1055
  • 175 Ogura T, Takagi W, Onda S. et al. Endoscopic ultrasound-guided drainage of a right liver abscess with a self-expandable metallic stent. Endoscopy 2015; 47: E397-E398
  • 176 Taguchi H, Tamai T, Numata M. et al. Endoscopic ultrasonography-guided transmural drainage of an infected hepatic cyst due to Edwardsiella tarda: a case report. Clin J Gastroenterol 2014; 7: 422-428
  • 177 Kodama R, Saegusa H, Ushimaru H. et al. Endoscopic ultrasonography-guided drainage of infected intracystic papillary adenocarcinoma of the liver. Clin J Gastroenterol 2015; 8: 335-339
  • 178 Nagamine N, Ueno N, Tomiyama T. et al. A pilot study on modified endoscopic variceal ligation using endoscopic ultrasonography with color Doppler function. Am J Gastroenterol 1998; 93: 150-155
  • 179 Andrade de Paulo G, Ardengh JC, Nakao FS. et al. Treatment of esophageal varices: a randomized controlled trial comparing endoscopic sclerotherapy and EUS-guided sclerotherapy of esophageal collateral veins. Gastrointest Endosc 2006; 63: 396-402
  • 180 Lahoti S, Catalano MF, Alcocer E. et al. Obliteration of esophageal varices using EUS-guided sclerotherapy with color Doppler. Gastrointest Endosc 2000; 51: 331-333
  • 181 Kassem MA, Salama AZ, Zakaria SM. et al. endoscopic ultrasonographic study of the azygos vein before and after endoscopic obliteration of esophagogastric varices by injection sclerotherapy. Endoscopy 2000; 32: 630-634
  • 182 Romero-Castro R, Ellrichmann M, Ortiz-Moyano C. et al. EUS-guided coil versus cyanoacrylate therapy for the treatment of gastric varices: a multicenter study (with videos). Gastrointest Endosc 2013; 78: 711-721
  • 183 Binmoeller KF, Weilert F, Shah JN. et al. EUS-guided transesophageal treatment of gastric fundal varices with combined coiling and cyanoacrylate glue injection (with videos). Gastrointest Endosc 2011; 74: 1019-1025
  • 184 Romero-Castro R, Pellicer-Bautista FJ, Jimenez-Saenz M. et al. EUS-guided injection of cyanoacrylate in perforating feeding veins in gastric varices: results in 5 cases. Gastrointest Endosc 2007; 66: 402-407
  • 185 Iwase H, Suga S, Morise K. et al. Color Doppler endoscopic ultrasonography for the evaluation of gastric varices and endoscopic obliteration with cyanoacrylate glue. Gastrointest Endosc 1995; 41: 150-154
  • 186 Lee YT, Chan FKL, Ng EKW. et al. EUS-guided injection of cyanoacrylate for bleeding gastric varices. Gastrointest Endosc 2000; 52: 168-174
  • 187 Bhat YM, Weilert F, Fredrick RT. et al. EUS-guided treatment of gastric fundal varices with combined injection of coils and cyanoacrylate glue: a large U. S. experience over 6 years (with video). Gastrointest Endosc 2016; 83: 1164-1172
  • 188 Tang RS, Teoh AY, Lau JY. EUS-guided cyanoacrylate injection for treatment of endoscopically obscured bleeding gastric varices. Gastrointest Endosc 2016; 83: 1032-1023
  • 189 Storm AC, Kumbhari V, Saxena P. et al. EUS-guided angiotherapy. Gastrointest Endosc 2014; 80: 164-165
  • 190 Gubler C, Bauerfeind P. Safe and successful endoscopic initial treatment and long-term eradication of gastric varices by endoscopic ultrasound-guided Histoacryl ( N -butyl-2-cyanoacrylate) injection. Scand J Gastroenterol 2014; 49: 1136-1142
  • 191 Gonzalez J-M, Giacino C, Pioche M. et al. Endoscopic ultrasound-guided vascular therapy: is it safe and effective?. Endoscopy 2012; 44: 539-542
  • 192 Rana SS, Bhasin DK, Rao C. et al. Endoscopic ultrasound-guided treatment of bleeding duodenal varix. Indian J Gastroenterol 2011; 30: 280-281
  • 193 Liao S-C, Yang S-S, Ko C-W. et al. A miniature ultrasound probe is useful in reducing rebleeding after endoscopic cyanoacrylate injection for hemorrhagic gastric varices. Scand J Gastroenterol 2013; 48: 1347-1353
  • 194 Romero-Castro R, Pellicer-Bautista F, Giovannini M. et al. Endoscopic ultrasound (EUS)-guided coil embolization therapy in gastric varices. Endoscopy 2010; 42: E35-E36
  • 195 Fujii-Lau LL, Law R, Wong Kee Song LM. et al. Endoscopic ultrasound (EUS)-guided coil injection therapy of esophagogastric and ectopic varices. Surg Endosc 2016; 30: 1396-1404
  • 196 Levy MJ, Wong Kee Song LM. et al. EUS-guided coil embolization for refractory ectopic variceal bleeding (with videos). Gastrointest Endosc 2008; 67: 572-574
  • 197 Kinzel J, Pichetshote N, Dredar S. et al. Bleeding from a duodenal varix: a unique case of variceal hemostasis achieved using EUS-guided placement of an embolization coil and cyanoacrylate. J Clin Gastroenterol 2014; 48: 362-364
  • 198 Krystallis C, McAvoy NC, Wilson J. et al. EUS-assisted thrombin injection for ectopic bleeding varices--a case report and review of the literature. QJM 2012; 105: 355-358
  • 199 Buscaglia JM, Dray X, Shin EJ. et al. A new alternative for a transjugular intrahepatic portosystemic shunt: EUS-guided creation of an intrahepatic portosystemic shunt (with video). Gastrointest Endosc 2009; 69: 941-947
  • 200 Binmoeller KF, Shah JN. Sa1428 EUS-guided transgastric intrahepatic portosystemic shunt using the Axios stent. Gastrointest Endosc 2011; 73: AB167
  • 201 Schulman AR, Ryou M, Aihara H. et al. EUS-guided intrahepatic portosystemic shunt with direct portal pressure measurements: a novel alternative to transjugular intrahepatic portosystemic shunting. Gastrointest Endosc 2017; 85: 243-247