Melanin Production Inhibitors from the West African Cassipourea congoensis

Dieudonné M. Takou; Alain F. Kamdem Waffo; Moses K. Langat; Jean D. Wansi; Lauren E. Mulcahy-Ryan; Sianne L. Schwikkard; Elizabeth I. Opara; Eduard Mas-Claret; Dulcie A. Mulholland

doi:10.1055/a-1006-2880

Planta Medica International Open, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Planta Medica International Open 2019; 6(02): e50-e56
DOI: 10.1055/a-1006-2880

Original Papers

Melanin Production Inhibitors from the West African Cassipourea congoensis

Autoren

Dieudonné M. Takou

¹Department of Chemistry, Faculty of Science, University of Douala, Douala, Cameroon
Alain F. Kamdem Waffo

¹Department of Chemistry, Faculty of Science, University of Douala, Douala, Cameroon

²Department of Chemistry, Natural Products Research Group, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, United Kingdom

³School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Africa
Moses K. Langat

²Department of Chemistry, Natural Products Research Group, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, United Kingdom

⁵Natural Capital and Plant Health Department, Jodrell Laboratory, Royal Botanic Gardens, Kew, Richmond, Surrey, United Kingdom
Jean D. Wansi

¹Department of Chemistry, Faculty of Science, University of Douala, Douala, Cameroon
Lauren E. Mulcahy-Ryan

⁴School of Life Sciences, Pharmacy and Chemistry, Kingston University, London, Kingston, United Kingdom
Sianne L. Schwikkard

⁴School of Life Sciences, Pharmacy and Chemistry, Kingston University, London, Kingston, United Kingdom
Elizabeth I. Opara

⁴School of Life Sciences, Pharmacy and Chemistry, Kingston University, London, Kingston, United Kingdom
Eduard Mas-Claret

²Department of Chemistry, Natural Products Research Group, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, United Kingdom
Dulcie A. Mulholland

²Department of Chemistry, Natural Products Research Group, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, United Kingdom

³School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Africa

Abstract

Cassipourea congoensis (syn. Cassipourea malosana) is used in African countries as a skin-lightening agent. Two previously unreported cycloartane triterpenoids, 26-hydroxy-3-keto-24-methylenecycloartan-30-oic acid 1 and 24-methylenecycloartan-3β,26,30-triol 2 along with the known mahuannin B 3, 7-methoxymahuannin B 4, 7-methoxygeranin A 5, methyl-3-(4-hydroxy-3-methoxyphenyl)-2E-propenoate, glycerol-1-alkanoate, (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enal 6 , (-)-syringaresinol 7, and stigmast-5-en-3-O-β-D-glucoside, were isolated from the roots of C. congoensis. The crude extract and compounds 1 and 5 were found to inhibit the production of melanin at 10 µM with low cytotoxicity validating the ethnomedicinal use of this plant.

Key words

Cassipourea congoensis - rhizophoraceae - cycloartane triterpenoids - 26-hydroxy-3-keto-24-methylenecycloartan-30-oic acid - 24-methylenecycloartan-3β - 26 - 30-triol - skin-lightening agents - tyrosinase inhibition and melanin inhibition

Volltext

Referenzen

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