CC BY-NC-ND 4.0 · Planta Medica International Open 2019; 6(02): e50-e56
DOI: 10.1055/a-1006-2880
Original Papers
Eigentümer und Copyright ©Georg Thieme Verlag KG 2019

Melanin Production Inhibitors from the West African Cassipourea congoensis

Dieudonné M. Takou
1  Department of Chemistry, Faculty of Science, University of Douala, Douala, Cameroon
,
Alain F. Kamdem Waffo
1  Department of Chemistry, Faculty of Science, University of Douala, Douala, Cameroon
2  Department of Chemistry, Natural Products Research Group, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, United Kingdom
3  School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Africa
,
Moses K. Langat
2  Department of Chemistry, Natural Products Research Group, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, United Kingdom
5  Natural Capital and Plant Health Department, Jodrell Laboratory, Royal Botanic Gardens, Kew, Richmond, Surrey, United Kingdom
,
Jean D. Wansi
1  Department of Chemistry, Faculty of Science, University of Douala, Douala, Cameroon
,
Lauren E. Mulcahy-Ryan
4  School of Life Sciences, Pharmacy and Chemistry, Kingston University, London, Kingston, United Kingdom
,
Sianne L. Schwikkard
4  School of Life Sciences, Pharmacy and Chemistry, Kingston University, London, Kingston, United Kingdom
,
Elizabeth I. Opara
4  School of Life Sciences, Pharmacy and Chemistry, Kingston University, London, Kingston, United Kingdom
,
Eduard Mas-Claret
2  Department of Chemistry, Natural Products Research Group, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, United Kingdom
,
Dulcie A. Mulholland
2  Department of Chemistry, Natural Products Research Group, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, United Kingdom
3  School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Africa
› Author Affiliations
Further Information

Publication History

received 22 February 2019
revised 07 August 2019

accepted 26 August 2019

Publication Date:
01 October 2019 (online)

Abstract

Cassipourea congoensis (syn. Cassipourea malosana) is used in African countries as a skin-lightening agent. Two previously unreported cycloartane triterpenoids, 26-hydroxy-3-keto-24-methylenecycloartan-30-oic acid 1 and 24-methylenecycloartan-3β,26,30-triol 2 along with the known mahuannin B 3, 7-methoxymahuannin B 4, 7-methoxygeranin A 5, methyl-3-(4-hydroxy-3-methoxyphenyl)-2E-propenoate, glycerol-1-alkanoate, (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enal 6 , (-)-syringaresinol 7, and stigmast-5-en-3-O-β-D-glucoside, were isolated from the roots of C. congoensis. The crude extract and compounds 1 and 5 were found to inhibit the production of melanin at 10 µM with low cytotoxicity validating the ethnomedicinal use of this plant.

Supplementary Material