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Horm Metab Res 2019; 51(11): 729-734
DOI: 10.1055/a-1010-6449
Endocrine Care
© Georg Thieme Verlag KG Stuttgart · New York

Could Vitamin D be Associated with Proliferative Diabetic Retinopathy? Evidence from Pooling Studies

Jing Yuan‡
1   Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
,
Jian-Bo Zhou‡
1   Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
,
Wei Zhao
2   Department of Geriatrics, Beijing Tongren Hospital, Capital Medical University, Beijing, China
,
Rui-Heng Zhang
3   Beijing Tongren Hospital, Capital Medical University, Beijing, China
,
Yao-Hua Cai
3   Beijing Tongren Hospital, Capital Medical University, Beijing, China
,
Lin-Ping Shu
3   Beijing Tongren Hospital, Capital Medical University, Beijing, China
,
Lu Qi
4   Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA
,
Jin-Kui Yang
1   Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
5   Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
› Author Affiliations
Further Information

Publication History

received 14 February 2019

accepted 05 September 2019

Publication Date:
04 November 2019 (online)

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Abstract

Contrasting data about the association between proliferative diabetic retinopathy (PDR) and vitamin D status remain unknown. First, a hospital-based cross-sectional study consisting of 889 diabetic retinopathy (DR) and non-DR (NDR) patients was admitted. Further the accumulated evidence was performed to explore the association and dose-response relationship. Our study indicated that the odd ratio for PDR in vitamin D deficiency (VDD) individuals was significantly increased (1.60, 95% CI 1.06–2.42), compared with NDR in vitamin D sufficiency individuals, adjusted by age, sex, diabetic duration, and HbA1c. Four studies plus our study with data on vitamin D levels in 4970 patients with PDR and NDR subjects are compared. Association between vitamin D deficiency and risk of PDR exists (OR=1.69, 95% CI 1.40–2.05; I2=0%, p=0.61). Association between a nonlinear trend for vitamin D decrease with risk of DR was significant (chi2=16.53, p=0.0003). No significant heterogeneity in identified studies was found (goodness of fit chi2=2.98, p=0.225). It is concluded that vitamin D deficiency is significantly associated with risk of proliferative diabetic retinopathy.

Key words

vitamin D - proliferative diabetic retinopathy - meta-analysis

Supplementary Material

 

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