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CC BY-NC-ND 4.0 · Planta Medica International Open 2020; 7(01): e12-e16
DOI: 10.1055/a-1094-9229
Original Papers
The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/). (2020) The Author(s).

Chemical Constituents of the Terrestrial Stems of Ephedra sinica and their PPAR-γ Ligand-Binding Activity

Yukiko Matsuo
1   School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Japan
,
Mayu Sasaki
1   School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Japan
,
Haruhiko Fukaya
1   School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Japan
,
Katsunori Miyake
1   School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Japan
,
Riko Takeuchi
2   School of Life Sciences, Tokyo University of Pharmacy and Life Science, Hachioji, Japan
,
Hidetoshi Kumata
2   School of Life Sciences, Tokyo University of Pharmacy and Life Science, Hachioji, Japan
,
Yoshihiro Mimaki
1   School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Japan
› Institutsangaben
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Publikationsverlauf

received 04. November 2019
revised 17. Dezember 2019

accepted 06. Januar 2020

Publikationsdatum:
12. Februar 2020 (online)

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Abstract

Bioassay-guided fractionation of the MeOH extract of Ephedra sinica terrestrial stems, using a PPAR-γ ligand binding assay, resulted in the isolation of 10 compounds, including one new bisabolane-type sesquiterpenoid (10). The structure of the new compound was determined by extensive spectroscopic analysis, including two-dimensional (2D) NMR. Among the isolated compounds, the sitosterol derivatives (1 and 2), flavonoid glucoside (7), and the new sesquiterpenoid (10), showed significant PPAR-γ ligand-binding activity.

Key words

Ephedra sinica - Ephedraceae - sesquiterpene - bisabolane - flavonoid - PPAR-γ

Supplementary Material

 

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