Struktur und Efferenzen der Substantia nigra pars compacta beim idiopathischen Parkinson-Syndrom

Peter Urban; Bjorn Falkenburger; Wolfgang H. Jost; Gerhard Ransmayr; Peter Riederer; Christian Winkler

doi:10.1055/a-1149-9280

Fortschritte der Neurologie · Psychiatrie, Table of Contents

Fortschr Neurol Psychiatr 2020; 88(09): 591-599
DOI: 10.1055/a-1149-9280

Übersicht

Struktur und Efferenzen der Substantia nigra pars compacta beim idiopathischen Parkinson-Syndrom

Structure and efferences of the substantia nigra pars compacta in Parkinson’s disease

Authors

Peter Urban

¹Abteilung für Neurologie, Asklepios Klinik Barmbek
Bjorn Falkenburger

²Klinik für Neurologie, Universitätsklinikum Carl Gustav Carus, Dresden
Wolfgang H. Jost

³Parkinson-Klinik Ortenau, Wolfach
Gerhard Ransmayr

⁴Klinik für Neurologie 2, Kepler Universitätsklinikum, Linz/Austria
Peter Riederer

⁵Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie, Universitätsklinikum Würzburg
Christian Winkler

⁶Krankenhaus Lindenbrunn, Coppenbrügge

Abstract

Zusammenfassung

Es besteht Konsens, dass das neuropathologische Merkmal des idiopathischen Parkinson-Syndroms (IPS) der neuronale Zellverlust der Substantia nigra pars compacta (SNc) in Verbindung mit einer Lewy-Pathologie ist. Die transsynaptische Ausbreitung der Lewy-Pathologie wird als wesentlich in der Parkinson-Pathogenese angesehen. Daher ist die Kenntnis präexistenter neuroanatomischer Verbindungen der SNc wesentlich. Wir beschreiben hier neuere tierexperimentelle Befunde zu den afferenten und efferenten Projektionen der SNc und diskutieren die Evidenz für und gegen die sequentielle transsynaptische Ausbreitung der Lewy-Pathologie in der Pathogenese des IPS.

Abstract

There is consensus that the neuropathological characteristic of Parkinson’s disease (PD) is the neuronal cell loss of the substantia nigra pars compacta (SNc) in connection with a Lewy pathology. The transsynaptic spread of Lewy pathology is considered essential in PD pathogenesis. Therefore, the knowledge of pre-existing neuroanatomical connections of the SNc is essential. We describe recent animal experiments on the afferent and efferent projections of the SNc and discuss the evidence for and against the sequential transsynaptic spread of Lewy pathology in the pathogenesis of PD.

Schlüsselwörter

idiopathisches Parkinson-Syndrom - Lewy-pathology - Substatia nigra - Neuropathologie

Keywords

Parkinson’s disease - Substantia nigra - Neuropathology - Lewy pathology

Full Text

References

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