The Effects of Vitamin D on Metabolic Profiles in Women with
                    Polycystic Ovary Syndrome: A Systematic Review

Ashley Williams; Jeganathan Ramesh Babu; Danielle D. Wadsworth; Donna Burnett; Thangiah Geetha

doi:10.1055/a-1160-9902

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 2020; 52(07): 485-491
DOI: 10.1055/a-1160-9902

Review

The Effects of Vitamin D on Metabolic Profiles in Women with Polycystic Ovary Syndrome: A Systematic Review

Authors

Ashley Williams

¹Department of Nutrition, Dietetics, and Hospitality Management, Auburn University, AL, USA
Jeganathan Ramesh Babu

¹Department of Nutrition, Dietetics, and Hospitality Management, Auburn University, AL, USA

²Boshell Metabolic Diseases and Diabetes Program, Auburn University, Auburn, AL, USA
Danielle D. Wadsworth

³School of Kinesiology, Auburn University, Auburn, AL, USA
Donna Burnett

¹Department of Nutrition, Dietetics, and Hospitality Management, Auburn University, AL, USA
Thangiah Geetha

¹Department of Nutrition, Dietetics, and Hospitality Management, Auburn University, AL, USA

²Boshell Metabolic Diseases and Diabetes Program, Auburn University, Auburn, AL, USA

Abstract

This systematic review aims to evaluate all epidemiological evidence in the literature linking the effect of vitamin D supplementation to metabolic and hormonal functions in women with polycystic ovary syndrome. The literature search was performed with two databases, namely Medline/PubMed and Web of Science, until 20 May 2019 for both observational and experimental studies concerning relationships between vitamin D and polycystic ovary syndrome. A total of ten studies with randomized, double-blinded, and placebo-controlled trial design from 2008 to 2019 were selected for this review. The inclusion criteria were women 18–45 years of age with polycystic ovary syndrome and comparing the metabolic or endocrine parameters between placebo and vitamin D supplementation groups. A total of ten studies were selected for this review. We found that vitamin D supplementation had a significant effect on insulin metabolism, total serum testosterone, hirsutism, C-reactive protein, and total antioxidant capacity in women with polycystic ovary syndrome. Evidence from available randomized controlled trials suggests that patients with polycystic ovary syndrome should take vitamin D supplementation for the beneficial effect of metabolic profiles. However, future research is needed regarding the beneficial effects in women who are non-obese with polycystic ovary syndrome, as well as more studies with larger sample sizes.

Key words

polycystic ovary syndrome - vitamin D - systematic review - randomized controlled trials

Full Text

References

References
1 Fica S, Albu A, Constantin M. et al. Insulin resistance and fertility in polycystic ovary syndrome. J Med Life 2008; 1: 415-422
2 Rashidi H, Toolabi M, Najafian M. et al. The relationship of serum 25-dihydroxy vitamin D3 concentrations with metabolic parameters in non-obese women with polycystic ovarian syndrome. Middle East Fertil Soc J 2016; 21: 264-268
3 Patra SK, Nasrat H, Goswami B. et al. Vitamin D as a predictor of insulin resistance in polycystic ovarian syndrome. Diabetes Metab Syndr 2012; 6: 146-149
4 He C, Lin Z, Robb SW. et al. Serum vitamin D levels and polycystic ovary syndrome: A systematic review and meta-analysis. Nutrients 2015; 7: 4555-4577
5 Javed Z, Papageorgiou M, Deshmukh H. et al. A Randomized, controlled trial of vitamin D supplementation on cardiovascular risk factors, hormones, and liver markers in women with polycystic ovary syndrome. Nutrients 2019; 11: 188
6 Fang F, Ni K, Cai Y. et al. Effect of vitamin D supplementation on polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Clin Pract 2017; 26: 53-60
7 Ostadmohammadi V, Jamilian M, Bahmani F. et al. Vitamin D and probiotic co-supplementation affects mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome. J Ovarian Res 2019; 12: 5
8 Thomson RL, Spedding S, Buckley JD. Vitamin D in the aetiology and management of polycystic ovary syndrome. Clin Endocrinol (Oxf) 2012; 77: 343-350
9 Demer LL, Hsu JJ, Tintut Y. Steroid Hormone Vitamin D: Implications for cardiovascular disease. Circ Res 2018; 122: 1576-1585
10 Hilger J, Friedel A, Herr R. et al. A systematic review of vitamin D status in populations worldwide. Br J Nutr 2014; 111: 23-45
11 Rashidi H, Ghaderian SB, Moradi L. The effect of vitamin D3 on improving lipid profile, fasting glucose and insulin resistance in polycystic ovary syndrome women with vitamin D deficiency. Middle East Fertil Soc J 2018; 23: 178-183
12 Lagunova Z, Porojnicu AC, Lindberg F. et al. The dependency of vitamin D status on body mass index, gender, age and season. Anticancer Res 2009; 29: 3713-3720
13 Parikh SJ, Edelman M, Uwaifo GI. et al. The relationship between obesity and serum 1,25-dihydroxy vitamin D concentrations in healthy adults. J Clin Endocrinol Metab 2004; 89: 1196-1199
14 Xue Y, Xu P, Xue K. et al. Effect of vitamin D on biochemical parameters in polycystic ovary syndrome women: A meta-analysis. Arch Gynecol Obstet 2017; 295: 487-496
15 Jamilian M, Foroozanfard F, Rahmani E. et al. Effect of two different doses of vitamin D supplementation on metabolic profiles of insulin-resistant patients with polycystic ovary syndrome. Nutrients 2017; 9: 1280
16 Pal L, Berry A, Coraluzzi L. et al. Therapeutic implications of vitamin D and calcium in overweight women with polycystic ovary syndrome. Gynecol Endocrinol 2012; 28: 965-968
17 Tehrani HG, Mostajeran F, Shahsavari S. The effect of calcium and vitamin D supplementation on menstrual cycle, body mass index and hyperandrogenism state of women with poly cystic ovarian syndrome. J Res Med Sci 2014; 19: 875-880
18 Dastorani M, Aghadavod E, Mirhosseini N. et al. The effects of vitamin D supplementation on metabolic profiles and gene expression of insulin and lipid metabolism in infertile polycystic ovary syndrome candidates for in vitro fertilization. Reprod Biol Endocrinol 2018; 16: 94
19 Maktabi M, Chamani M, Asemi Z. The effects of vitamin D supplementation on metabolic status of patients with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial. Horm Metab Res 2017; 49: 493-498
20 Raja-Khan N, Shah J, Stetter CM. et al. High-dose vitamin D supplementation and measures of insulin sensitivity in polycystic ovary syndrome: A randomized, controlled pilot trial. Fertil Steril 2014; 101: 1740-1746
21 Trummer C, Schwetz V, Kollmann M. et al. Effects of vitamin D supplementation on metabolic and endocrine parameters in PCOS: A randomized controlled trial. Eur J Nutr 2019; 58: 2019-2028
22 Foroozanfard F, Jamilian M, Bahmani F. et al. Calcium plus vitamin D supplementation influences biomarkers of inflammation and oxidative stress in overweight and vitamin D-deficient women with polycystic ovary syndrome: A randomized double-blind placebo-controlled clinical trial. Clin Endocrinol (Oxf) 2015; 83: 888-894
23 Wehr E, Pieber TR, Obermayer-Pietsch B. Effect of vitamin D3 treatment on glucose metabolism and menstrual frequency in polycystic ovary syndrome women: a pilot study. J Endocrinol Invest 2011; 34: 757-763
24 Kern PA, Ranganathan S, Li C. et al. Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab 2001; 280: E745-E751
25 Federici M, Hribal ML, Menghini R. et al. Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha. J Clin Invest 2005; 115: 3494-3505
26 Monroy A, Kamath S, Chavez AO. et al. Impaired regulation of the TNF-alpha converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: A new mechanism of insulin resistance in humans. Diabetologia 2009; 52: 2169-2181
27 Tripathy D, Daniele G, Fiorentino TV. et al. Pioglitazone improves glucose metabolism and modulates skeletal muscle TIMP-3-TACE dyad in type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled, mechanistic study. Diabetologia 2013; 56: 2153-2163