Phlebologie 2021; 50(06): 384-389
DOI: 10.1055/a-1171-4974
Kasuistik

Ein interessanter Fall: Exanthem bei akuter Niereninsuffizienz

An interesting case: acute renal failure with exanthema
Sandra Schreiner
Universitätsklinikum Hamburg-Eppendorf
,
Stefan Werner Schneider
Universitätsklinikum Hamburg-Eppendorf
,
Wilhelm Kath
Universitätsklinikum Hamburg-Eppendorf
› Author Affiliations

Zusammenfassung

Wir berichten über einen Patienten, der ein Exanthem im Sinne palpabler Purpura bei akuter Niereninsuffizienz zeigte. Die Histologie der Haut und direkte Immunfluoreszenz wiesen eine IgA-Vaskulitis nach. In der Urinuntersuchung zeigten sich Akanthozyten, die diagnostische Nierenbiopsie bestätigte den Verdacht einer begleitenden Glomerulonephritis. Unter hochdosierter Steroidtherapie kam es zur Besserung des Hautbefundes und der Retentionsparameter.

Abstract

We report about a patient with palpable purpura in combination with an acute renal failure. The biopsy of the skin and direct immunofluorescence show the appearence of an IgA-vasculitis. In the urine tests acanthoyctes were shown, the diagnostic renal biopsy confirms the suspected accompanyoning glomerulonephritis. After treatment with highdose corticosteroids the skin lesions and the renal function improve.



Publication History

Article published online:
09 October 2020

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • Literatur

  • 1 Yang YH, Hung CF, Hsu CR. et al. A nationwide survey on epidemiological characteristics of childhood Henoch–Schönlein purpura in Taiwan. Rheumatology 2005; 44 (05) 618-622
  • 2 Audemard-Verger A, Pillebout E, Guillevin L. et al. IgA vasculitis (Henoch-Shönlein purpura) in adults: Diagnostic and therapeutic aspects. Autoimmun Rev 2015; 14 (07) 579-585
  • 3 García-Porrúa C, Calviño MC, Llorca J. et al. Henoch-Schönlein purpura in children and adults: clinical differences in a defined population. Semin Arthritis Rheum 2002; 32 (03) 149-156
  • 4 Pillebout E. Adult Henoch-Schönlein purpura. Presse Med 2008; 37 (12) 1773-1778
  • 5 Plewig G, Ruzicka T, Kaufmann R. et al. Braun-Falco’s Dermatologie, Venerologie und Allergologie. Springer; 2018: 1156-1159
  • 6 Pillebout E, Thervet E, Hill G. et al. Henoch-Schönlein Purpura in adults: outcome and prognostic factors. J Am Soc Nephrol 2002; 13 (05) 1271-1278
  • 7 Audemard-Verger A, Terrier B, Dechartres A. et al. Characteristics and Management of IgA Vasculitis (Henoch-Schönlein) in Adults: Data From 260 Patients Included in a French Multicenter Retrospective Survey. Arthritis Rheumatol 2017; 69 (09) 1862-1870
  • 8 Huber AM, King J, McLaine P. et al. A randomized, placebo-controlled trial of prednisone in early Henoch Schonlein purpura [ISRCTN85109383]. BMC Med 2004; 2: 7
  • 9 Pillebout E, Alberti C, Guillevin L. et al. Addition of cyclophosphamide to steroids provides no benefit compared with steroids alone in treating adult patients with severe Henoch Schonlein purpura. Kidney Int 2010; 78: 495-502
  • 10 Callen JP. Colchicine is effective in controlling chronic cutaneous leukocytoclastic vasculitis. J Am Acad Dermatol 1985; 13 (02) 193-200
  • 11 Shin JI, Park JM, Shin YH. et al. Can azathioprine and steroids alter the progression of severe Henoch-Schonlein nephritis in children?. Pediatr Nephrol 2005; 20: 1087-1092
  • 12 Carlson JA, Cavaliere LF, Grant-Kels JM. Cutaneous vasculitis: diagnosis and management. Clin Dermatol 2006; 24: 414-429 DOI: 10.1016/j.clindermatol.2006.07.007.
  • 13 Ren P, Han F, Chen L. et al The combination of mycophenolate mofetil with corticosteroids induces remission of Henoch-Schönlein purpura nephriti. Am J Nephrol 2012; 36 (03) 271-277 DOI: 10.1159/000341914.
  • 14 Hernández-Rodríguez J, Carbonell C, Mirón-Canelo JA. et al. Rituximab treatment for IgA vasculitis. A systematic review. Autoimmun Rev 2020; DOI: 10.1016/j.autrev.2020.102490.
  • 15 Sunderkotter C, Roth J, Bonsmann G. Leukocytoclastic vas-culitis. Hautarzt 2004; 55: 759-783 ; Quiz 784–785
  • 16 Müller CSL, Vogt T, Pföhler C. et al. Diagnostik und histologische Besonderheiten der kutanen Vaskulitiden/Vaskulopathien. Akt Dermatol 2016; 42: 286-301