CC BY-NC-ND 4.0 · Planta Medica International Open 2020; 07(03): e106-e113
DOI: 10.1055/a-1174-1197
Original Papers

Cytotoxic, Anti-bacterial, and Wound-healing Activity of Prenylated Phenols from the Kurdish Traditional Medicinal Plant Onobrychis Carduchorum (Fabaceae)

1  DISIT - Università del Piemonte Orientale, Alessandria, Italy
,
Faiq H. S. Hussain
2  Medical Analysis Department, Faculty of Science, Tishk International University, Erbil, Kurdistan Region-Iraq
,
Hawraz Ibrahim M. Amin
3  Chemistry Department, College of Science, Salahaddin University-Erbil, Erbil, Iraq
4  Department of Pharmacy, Paitaxt Technical Institute-Private, Erbil, Iraq
,
Elisa Bona
5  DISIT - Università del Piemonte Orientale, Vercelli, Italy
,
Elisa Gamalero
1  DISIT - Università del Piemonte Orientale, Alessandria, Italy
,
Novello Giorgia
1  DISIT - Università del Piemonte Orientale, Alessandria, Italy
,
Rosamaria Lappano
6  Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy.
,
Marianna Talia
6  Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy.
,
Marcello Maggiolini
6  Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy.
,
Miriam Bazzicalupo
7  DISTAV – Università degli Studi di Genova, Genova, Italy
,
Laura Cornara
7  DISTAV – Università degli Studi di Genova, Genova, Italy
› Author Affiliations
Funding: This work was financially supported by Tishk International University, Erbil, Iraq, and by the University of Eastern Piedmont (UPO), according to the Cultural Co-operation Framework Memorandum of Understanding between the two Institutions.
  

Abstract

Onobrychis carduchorum (Fabaceae) is a plant widely employed in Kurdish traditional medicine to cure wounds, inflammations, and other skin diseases. We could isolate ten different polyphenols from the acetone extract of this plant: 14 are isoflavones, having a genistein skeleton; 57 are flavanones, having a naringenin skeleton; and 810 are prenylated dihydro-stilbenes. In particular, 810 have been isolated, so far, only from Glycyrrhiza glabra (liquorice). Many of the above prenylated phenols showed significant toxicity on some human breast cancer cell lines, and a relevant growth inhibition of Staphylococcus aureus strains. In addition, 9 and 10 had marked wound healing activity. It is suggested that these bioactivities are responsible, at least partly, for the plant’s traditional use.

Supporting Information



Publication History

Received: 02 December 2019
Received: 23 January 2020

Accepted: 06 May 2020

Publication Date:
05 June 2020 (online)

© 2020. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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