Abstract
Endothelial dysfunction is the important early step in the development of
atherosclerosis. Hypothyroidism caused by Hashimoto’s thyroiditis and
other thyroid disease is one of the risk factors of endothelial dysfunction. The
present study tried to investigate the endothelial function and its associated
factors in Hashimoto thyroiditis with euthyroidism. A total of 95 newly
diagnosed Hashimoto’s thyroiditis patients with euthyroidism and 45
healthy controls were studied. Hashimoto’s patients were divided into 3
subgroups namely, single thyroglobulin antibody (TGAb) positive subgroup, single
thyroid peroxidase antibody (TPOAb) positive subgroup, and both TGAb and TPOAb
positive subgroup. Endothelial function was tested by the reactive hyperemia
index (RHI). Hashimoto’s thyroiditis patients had lower RHI than healthy
controls (1.73±0.42 vs 1.96±0.51, p<0.05).
Hashimoto’s thyroiditis with single TGAb positive patients had higher
RHI than single TPOAb positive (1.98±0.57 vs. 1.69±0.33,
p<0.05) and TGAB + TPOAb positive patients (1.98±0.57
vs. 1.68±0.42, p<0.05). RHI were negatively associated with
total cholesterol (TC, r=−0.215, p<0.05), low density
lipoprotein cholesterol (LDL-C, r=−0.268, p<0.05),
triglyceride (TG, r=−0.192, p<0.05), and TPOAb
(r=−0.288, p<0.05). In the regression analysis, LDL-C
(β=−0.146, p<0.05), TG
(β=−0.034, p<0.05) and TPOAb
(β=−0.001, p<0.05) were independently associated
with RHI. Hashimoto’s patients had poor endothelial function. TPOAb
levels were negatively associated with endothelial function.
Key words
Hashimoto’s thyroiditis - endothelial dysfunction - thyroid peroxidase antibody
