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Planta Med 2020; 86(11): 776-781
DOI: 10.1055/a-1179-1050
Biological and Pharmacological Activity
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

α-Glucosidase Inhibitory Depsidones from the Lichen Parmotrema tsavoense

Thuc-Huy Duong
1   Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Vietnam
2   Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam
,
Tai-Xuan-Hoa Hang
3   Department of Chemistry, Ho Chi Minh City University of Education, Ho Chi Minh City, Vietnam
,
Pierre Le Pogam
4   Équipe “Pharmacognosie-Chimie des Substances Naturelles”, BioCIS, Université Paris-Sud, CNRS, Université Paris-Saclay, Châtenay-Malabry, France
,
Thanh-Nha Tran
3   Department of Chemistry, Ho Chi Minh City University of Education, Ho Chi Minh City, Vietnam
,
Dinh-Hung Mac
5   Department of Organic Chemistry, University of Science, Vietnam National University, Ha Noi, Vietnam
,
Minh-Hiep Dinh
6   Management Board of Agricultural Hi-Tech Park, Ho Chi Minh City, Vietnam
,
Jirapast Sichaem
7   Faculty of Science and Technology, Thammasat University Lampang Campus, Lampang, Thailand
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Weitere Informationen

Publikationsverlauf

received 17. Januar 2020
revised 01. Mai 2020

accepted 11. Mai 2020

Publikationsdatum:
29. Mai 2020 (online)

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Abstract

Chemical investigation of the lichen Parmotrema tsavoense led to the isolation of 5 new depsidones, parmosidones F – J (1 – 5). These compounds were structurally elucidated using spectroscopic methods including HRESIMS and 2D NMR data. Compounds 1, 3, and 4 were evaluated for their inhibition of α-glucosidase. All exhibited potent α-glucosidase inhibitory activity with IC50 values ranging from 10.7 to 17.6 µM, which was much lower than that of the positive control acarbose (IC50 449 µM).

Key words

Parmeliaceae - Parmotrema tsavoense - lichen - parmosidones F – J - depsidone - α-glucosidase inhibition

Supporting Information

    HRESIMS and 1D, 2D-NMR spectra of compounds 1 – 5 are available as Supporting Information.

  • Supporting Information
 

  • References

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