Die Gruppe der neutrophilen Dermatosen umfasst verschiedene, nicht infektiöse Erkrankungen,
die durch eine Akkumulation von neutrophilen Granulozyten in der Haut gekennzeichnet
sind. Das klinische Erscheinungsbild der Dermatosen ist heterogen und reicht von sterilen
Pusteln über oberflächliche oder tiefe Gewebsinfiltration bis hin zu Nekrosen. Dieser
Artikel soll einen Überblick über die wichtigsten neutrophilen Dermatosen geben.
Abstract
The group of neutrophilic dermatoses includes various non-infectious diseases characterised
by an accumulation of neutrophilic granulocytes in the skin. The clinical appearance
of these dermatoses is diverse and ranges from sterile pustules to superficial or
deep tissue infiltration and necrosis. The skin lesions are defined histopathologically
by a diffuse infiltrate of neutrophilic granulocytes without evidence of infection.
Evidence suggests a pathogenetic role of selected proinflammatory cytokines of the
interleukin (IL)-1 cytokine family, leading to sterile neutrophil-rich inflammation
of the skin. The classification of neutrophil dermatoses is histopathologically based
on the cutaneous localisation of neutrophil accumulation. The article provides an
overview of the most important clinical features of neutrophilic dermatoses, their
causes and treatment options.
Schlüsselwörter
neutrophile Dermatose - Pyoderma gangraenosum - Sweet-Syndrom - Akut generalisierte
exanthematische Pustulose
Key words
neutrophilic dermatosis - pyoderma gangraenosum - Sweet syndrome - acute generalized
exanthematous pustulosis
