Download PDF
Arthritis und Rheuma 2021; 41(01): 56-57
DOI: 10.1055/a-1253-0075
Kinderrheumatologie kompakt

Literaturübersicht zur Therapie der CNO mit TNF-α-Inhibitoren

Toni Hospach∗
1   Zentrum für pädiatrische Rheumatologie am Klinikum Stuttgart (ZEPRAS)
,
Christian Hedrich∗
2   Department of Women’s and Children’s Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK; Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust, Liverpool, UK
› Author Affiliations
› Further Information
    Permissions and Reprints

Die optimale Therapie der Chronisch Nichtbakteriellen Osteomyelitis (CNO) ist zum jetzigen Zeitpunkt nicht geklärt. Neben NSAR werden kurzfristig Glukokortikoide, konventionelle Basismedikamente (Disease Modifying Antirheumatic Drugs: kDMARDs), Bisphosphonate und Biologika eingesetzt. Die vorliegende Arbeit thematisiert diesen differenzialtherapeutischen Aspekt mit Schwerpunkt auf den Tumornekrosefaktor-α-Inhibitoren (TNF-i).



Publication History

Article published online:
26 February 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • Literatur

  • 1 Aktay Ayaz N, Topaloglu R, Özaltin F. et al A case of chronic recurrent multifocal osteomyelitis successfully treated with etanercept. Pediatric Rheumatology 2008; 6: P191
    CrossrefGoogle Scholar
  • 2 Andreasen CM, Jurik AG, Deleuran BW. et al 2020. ‘Pamidronate in chronic non-bacterial osteomyelitis: a randomized, double-blinded, placebo-controlled pilot trial’, Scand J Rheumatol 2020; 49: 312-322
    Google Scholar
  • 3 Beck C, Morbach H, Beer M. et al Chronic nonbacterial osteomyelitis in childhood: prospective follow-up during the first year of anti-inflammatory treatment. Arthritis Res Ther 2010; 12 (02) R74: 1-11
    CrossrefGoogle Scholar
  • 4 Borzutzky A, Stern S, Reiff A. et al Pediatric chronic nonbacterial osteomyelitis. Pediatrics 2012; 130: e1190-1197
    CrossrefPubMedGoogle Scholar
  • 5 Carpenter E, Jackson MA, Friesen CA. et al Crohn’s-associated chronic recurrent multifocal osteomyelitis responsive to infliximab. J Pediatr 2004; 144: 541-544
    CrossrefPubMedGoogle Scholar
  • 6 Deutschmann A, Mache CJ, Bodo K. et al Successful treatment of chronic recurrent multifocal osteomyelitis with tumor necrosis factor-alpha blockage. Pediatrics 2005; 116: 1231-1233
    CrossrefPubMedGoogle Scholar
  • 7 Eisenstein EM, Syverson GD, Vora SS, Williams CB. Combination therapy with methotrexate and etanercept for refractory chronic recurrent multifocal osteomyelitis. J Rheumatol 2011; 38 (04) 782-783 DOI: 10.3899/jrheum.100431.
    CrossrefPubMedGoogle Scholar
  • 8 Eleftheriou D, Gerschman T, Sebire N. et al Biologic therapy in refractory chronic non-bacterial osteomyelitis of childhood. Rheumatology (Oxford) 2010; 49: 1505-1512
    CrossrefPubMedGoogle Scholar
  • 9 Girschick H, Finetti M, Orlando F. et al Organisation Paediatric Rheumatology International Trials, and registry the Eurofever. The multifaceted presentation of chronic recurrent multifocal osteomyelitis: a series of 486 cases from the Eurofever international registry. Rheumatology (Oxford) 2018; 57: 1504
    CrossrefPubMedGoogle Scholar
  • 10 Hedrich CM, Morbach H, Reiser C, Girschick HJ. New Insights into Adult and Paediatric Chronic Non-bacterial Osteomyelitis CNO. Curr Rheumatol Rep 2020; 22: 52
    CrossrefPubMedGoogle Scholar
  • 11 Hedrich CM, Girschick HJ. Chronic non-bacterial osteomyelitis. In: Textbook of Autoinflammation. Cham, Switzerland: Springer Nature Switzerland; 2019
    CrossrefGoogle Scholar
  • 12 Hofmann SR, Schnabel A, Rosen-Wolff A. et al 2016. ‘Chronic Nonbacterial Osteomyelitis: Pathophysiological Concepts and Current Treatment Strategies. J Rheumatol 2016; 43: 1956-1964
    CrossrefPubMedGoogle Scholar
  • 13 Hospach T, Langendoerfer M, von Kalle T. et al Spinal involvement in chronic recurrent multifocal osteomyelitis (CRMO) in childhood and effect of pamidronate. Eur J Pediatr 2010; 169: 1105-1111
    CrossrefPubMedGoogle Scholar
  • 14 Jansson A, Renner ED, Ramser J. et al Classification of non-bacterial osteitis: retrospective study of clinical, immunological and genetic aspects in 89 patients. Rheumatology (Oxford) 2007; 46: 154-160
    CrossrefPubMedGoogle Scholar
  • 15 Jansson A, Borte M, Hospach A. et al Diagnostik und Therapie der nichtbakteriellen Osteomyelitis. Monatsschr Kinderheilkd 2014; 162: 539-545
    CrossrefGoogle Scholar
  • 16 Kaiser D, Bolt I, Hofer M. et al Chronic nonbacterial osteomyelitis in children: a retrospective multicenter study. Pediatr Rheumatol Online J 2015; 13: 25
    CrossrefPubMedGoogle Scholar
  • 17 Kerrison C, Davidson JE, Cleary AG, Beresford MW. Pamidronate in the treatment of childhood SAPHO syndrome. Rheumatology (Oxford) 2004; 43: 1246-1251
    CrossrefPubMedGoogle Scholar
  • 18 Pastore S, Ferrara G, Monasta L. et al Chronic nonbacterial osteomyelitis may be associated with renal disease and bisphosphonates are a good option for the majority of patients. Acta Paediatr 2016; 105: e328-e333
    CrossrefPubMedGoogle Scholar
  • 19 Roderick MR, R.Shah R, Rogers V. et al Chronic recurrent multifocal osteomyelitis (CRMO) – advancing the diagnosis. Pediatr Rheumatol Online J 2016; 14: 47
    CrossrefPubMedGoogle Scholar
  • 20 Schnabel A, Range U, Hahn G. et al Treatment Response and Longterm Outcomes in Children with Chronic Nonbacterial Osteomyelitis. J Rheumatol 2017; 44: 1058-1065
    CrossrefPubMedGoogle Scholar
  • 21 Schwarz T, Petzke S, Morbach H. et al Juvenile chronic non-bacterial osteomyelitis (CNO): Long term course of disease and response to treatment in a large institutional cohort. Pediatric Rheumatology 2015; 13: P178
    CrossrefGoogle Scholar
  • 22 Schwarz T, Oommen P, Windschall D. et al Protokolle zur Klassifikation, Überwachung und Therapie der chronisch nichtbakteriellen Osteomyelitis. Arthritis und Rheuma 2018; 4: 282-288
    Google Scholar
  • 23 Tlougan BE, Podjasek JO, O’Haver J. et al Chronic recurrent multifocal osteomyelitis (CRMO) and synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome with associated neutrophilic dermatoses: a report of seven cases and review of the literature. Pediatr Dermatol 2009; 26: 497-505
    CrossrefPubMedGoogle Scholar
  • 24 Wipff J, Costantino F, Lemelle I. et al A large national cohort of French patients with chronic recurrent multifocal osteitis’. Arthritis Rheumatol 2015; 67: 1128-1137
    CrossrefPubMedGoogle Scholar
  • 25 Wolber C, David-Jelinek K, Udvardi A. et al [Successful therapy of sacroiliitis in SAPHO syndrome by etanercept]. Wien Med Wochenschr 2011; 161: 204-208
    CrossrefPubMedGoogle Scholar
  • 26 Zhao Y, Chauvin NA, Jaramillo D, Burnham JM. Aggressive Therapy Reduces Disease Activity without Skeletal Damage Progression in Chronic Nonbacterial Osteomyelitis. J Rheumatol 2015; 42: 1245-1251
    CrossrefGoogle Scholar
  • 27 Zhao Y, Wu EY, Oliver MS. et al Group Chronic Nonbacterial Osteomyelitis/Chronic Recurrent Multifocal Osteomyelitis Study, Arthritis the Childhood, Vasculitis Autoinflammatory Rheumatology Research Alliance Scleroderma, and Subcommittee Rare Diseases. Consensus Treatment Plans for Chronic Nonbacterial Osteomyelitis Refractory to Nonsteroidal Antiinflammatory Drugs and/or With Active Spinal Lesions. Arthritis Care Res (Hoboken) 2018; 70: 1228-1237
    CrossrefPubMedGoogle Scholar
  • 28 Ziobrowska-Bech A, Fiirgaard B, Heuck C. et al Ten-year review of Danish children with chronic non-bacterial osteitis. Clin Exp Rheumatol 2013; 31: 974-979
    PubMedGoogle Scholar