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Exp Clin Endocrinol Diabetes 2021; 129(10): 762-769
DOI: 10.1055/a-1274-0998
Article

The Effect of Immunosuppression on Selected Antioxidant Parameters in Patients with Graves’ Disease with Active Thyroid-Associated Orbitopathy

Magdalena Londzin-Olesik 
1   Departments of Endocrinology and Neuroendocrine Tumors, and Pathophysiology and Endocrinology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice
,
Beata Kos-Kudla
1   Departments of Endocrinology and Neuroendocrine Tumors, and Pathophysiology and Endocrinology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice
,
Jacek Karpe
2   Department of Anaesthesiology and Intensive Therapy in Zabrze, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice
,
Aleksandra Nowak
3   Science Students’ Association, Department of Pathophysiology and Endocrinology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice
,
Mariusz Nowak
4   Division of Pathophysiology, Department of Pathophysiology and Endocrinology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice
› Author Affiliations Funding This work was supported by the Medical University of Silesia.
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Abstract

Background and Study Aims Thyroid-associated orbitopathy, the most common extrathyroidal manifestation of Graves’ disease, is an autoimmune inflammation of orbital soft tissue. We report the study assessing the effect of immunosuppressive treatment with methylprednisolone on selected antioxidant parameters in patients with Graves’ disease with active thyroid-associated orbitopathy.

Patients and Methods Activity and serum levels of selected antioxidant parameters as well as lipid peroxidation products were determined in a group of 56 patients with active thyroid-associated orbitopathy at three time-points: at baseline, after the discontinuation of intravenous methylprednisolone treatment and at 3 months after the discontinuation of additional oral methylprednisolone treatment. A control group consisted of 20 healthy age- and sex-matched volunteers.

Results We found an increased activity of superoxide dismutase and glutathione peroxidase and increased serum levels of uric acid, malondialdehyde and conjugated dienes, as well as a reduced activity of paraoxonase-1 and reduced serum vitamin C level in the study group at baseline. Systemic intravenous and oral methylprednisolone therapy led to normalization of activity and concentration of the most studied parameters.

Conclusion Results of our study confirmed that oxidative stress is one of the factors involved in the pathogenesis of thyroid-associated orbitopathy and the methyloprednisolone treatment is effective in reducing both clinical symptoms and oxidative stress in patients with this disease.

Key words

Graves’ orbitopathy - corticosteroids - antioxidant parameters - lipid peroxidation products - oxidative stress 


Publication History

Received: 25 March 2020
Received: 22 September 2020

Accepted: 29 September 2020

Article published online:
06 November 2020

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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