Int J Sports Med 2021; 42(07): 602-609
DOI: 10.1055/a-1297-4475
Physiology & Biochemistry

Activation of Mechanoreflex, but not Central Command, Delays Heart Rate Recovery after Exercise in Healthy Men

1   Exercise Hemodynamic Laboratory, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil
,
Leandro Campos de Brito
1   Exercise Hemodynamic Laboratory, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil
2   School of Physical Education and Sport, Sao Paulo, University of Sao Paulo, Brazil
,
Rafael Yokoyama Fecchio
1   Exercise Hemodynamic Laboratory, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil
,
Patricia Nascimento de Sousa
1   Exercise Hemodynamic Laboratory, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil
,
Natan Daniel Silva
1   Exercise Hemodynamic Laboratory, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil
,
Patricia Guimaraes Couto
2   School of Physical Education and Sport, Sao Paulo, University of Sao Paulo, Brazil
,
Andrea Pio de Abreu
3   Hipertension Unit, General Hospital, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
,
Giovanio Vieira da Silva
3   Hipertension Unit, General Hospital, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
,
Decio Mion
3   Hipertension Unit, General Hospital, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
,
David A. Low
4   Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom of Great Britain and Northern Ireland
,
Claudia Lucia de Moraes Forjaz
1   Exercise Hemodynamic Laboratory, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil
› Institutsangaben
Funding: This study was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP – 2013/04997-0 and 2013/05519-4), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq – 304436/2018-6) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES-PROEX - 0001).

Abstract

This study tested the hypotheses that activation of central command and muscle mechanoreflex during post-exercise recovery delays fast-phase heart rate recovery with little influence on the slow phase. Twenty-five healthy men underwent three submaximal cycling bouts, each followed by a different 5-min recovery protocol: active (cycling generated by the own subject), passive (cycling generated by external force) and inactive (no-cycling). Heart rate recovery was assessed by the heart rate decay from peak exercise to 30 s and 60 s of recovery (HRR30s, HRR60s fast phase) and from 60 s-to-300 s of recovery (HRR60−300s slow phase). The effect of central command was examined by comparing active and passive recoveries (with and without central command activation) and the effect of mechanoreflex was assessed by comparing passive and inactive recoveries (with and without mechanoreflex activation). Heart rate recovery was similar between active and passive recoveries, regardless of the phase. Heart rate recovery was slower in the passive than inactive recovery in the fast phase (HRR60s=20±8vs.27 ±10 bpm, p<0.01), but not in the slow phase (HRR60−300s=13±8vs.10±8 bpm, p=0.11). In conclusion, activation of mechanoreflex, but not central command, during recovery delays fast-phase heart rate recovery. These results elucidate important neural mechanisms behind heart rate recovery regulation.



Publikationsverlauf

Eingereicht: 01. Juni 2020

Angenommen: 14. Oktober 2020

Artikel online veröffentlicht:
22. Dezember 2020

© 2020. Thieme. All rights reserved.

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Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • References

  • 1 Fisher JP, Young CN, Fadel PJ. Autonomic adjustments to exercise in humans. Compr Physiol 2015; 5: 475-512
  • 2 Potts JT. Inhibitory neurotransmission in the nucleus tractus solitarii: Implications for baroreflex resetting during exercise. Exp Physiol 2006; 91: 59-72
  • 3 Gladwell VF, Coote JH. Heart rate at the onset of muscle contraction and during passive muscle stretch in humans: A role for mechanoreceptors. J Physiol 2002; 540: 1095-1102
  • 4 Gladwell VF, Fletcher J, Patel N. et al. The influence of small fibre muscle mechanoreceptors on the cardiac vagus in humans. J Physiol 2005; 567: 713-721
  • 5 Nobrega AC, Williamson JW, Friedman DB. et al. Cardiovascular responses to active and passive cycling movements. Med Sci Sports Exerc 1994; 26: 709-714
  • 6 Williamson JW, Nobrega AC, Winchester PK. et al. Instantaneous heart rate increase with dynamic exercise: central command and muscle-heart reflex contributions. J Appl Physiol (1985) 1995: 1273-1279
  • 7 Peçanha T, Silva-Junior ND, Forjaz CL. Heart rate recovery: Autonomic determinants, methods of assessment and association with mortality and cardiovascular diseases. Clin Physiol Funct Imaging 2014; 34: 327-339
  • 8 Imai K, Sato H, Hori M. et al. Vagally mediated heart rate recovery after exercise is accelerated in athletes but blunted in patients with chronic heart failure. J Am Coll Cardiol 1994; 24: 1529-1535
  • 9 Coote JH. Recovery of heart rate following intense dynamic exercise. Exp Physiol 2010; 95: 431-440
  • 10 Michael S, Graham KS, Davis GM. Cardiac autonomic responses during exercise and post-exercise recovery using heart rate variability and systolic time intervals—A review. Front Physiol 2017; 8: 301
  • 11 Carter R, Watenpaugh DE, Wasmund WL. et al. Muscle pump and central command during recovery from exercise in humans. J Appl Physiol (1985) 1999; 87: 1463-1469
  • 12 Shibasaki M, Sakai M, Oda M. et al. Muscle mechanoreceptor modulation of sweat rate during recovery from moderate exercise. J Appl Physiol (1985) 2004; 96: 2115-2119
  • 13 Romero SA, Minson CT, Halliwill JR. The cardiovascular system after exercise. J Appl Physiol (1985) 2017; 122: 925-932
  • 14 Peçanha T, Brito LC, Fecchio RY. et al. Metaboreflex activation delays heart rate recovery after aerobic exercise in never-treated hypertensive men. J Physiol 2016; 594: 6211-6223
  • 15 Peçanha T, Low DA, Brito LC. et al. Effects of postexercise cooling on heart rate recovery in normotensive and hypertensive men. Clin Physiol Funct Imaging 2020; 40: 114-121
  • 16 Malachias M, Gomes M, Nobre F. et al. 7th Brazilian Guideline of Arterial Hypertension: Chapter 2 - Diagnosis and Classification. Arq Bras Cardiol 2016; 107: 7-13
  • 17 Harriss DJ, MacSween A, Atkinson G. Ethical standards in sport and exercise science research: 2020 update. Int J Sports Med 2019; 40: 813-817
  • 18 Lu C-L, Zou X, Orr WC. et al. Postprandial changes of sympathovagal balance measured by heart rate variability. Dig Dis Sci 1999; 44: 857-861
  • 19 Byrne C, Lim CL. The ingestible telemetric body core temperature sensor: a review of validity and exercise applications. Br J Sports Med 2007; 41: 126-133
  • 20 Lacombe SP, Goodman JM, Spragg CM. et al. Interval and continuous exercise elicit equivalent postexercise hypotension in prehypertensive men, despite differences in regulation. Appl Physiol Nutr Metab 2011; 36: 881-891
  • 21 Bartels R, Neumamm L, Pecanha T. et al. SinusCor: An advanced tool for heart rate variability analysis. Biomed Eng Online 2017; 16: 1-15
  • 22 Peçanha T, Bartels R, Brito LC. et al. Methods of assessment of the post-exercise cardiac autonomic recovery: A methodological review. Int J Cardiol 2017; 227: 795-802
  • 23 Bartels R, Prodel E, Laterza MC. et al. Heart rate recovery fast-to-slow phase transition: Influence of physical fitness and exercise intensity. Ann Noninvasive Electrocardiol 2018; 23: 1-7
  • 24 Parati G, Di Rienzo M, Bertinieri G. et al. Evaluation of the baroreceptor-heart rate reflex by 24-hour intra-arterial blood pressure monitoring in humans. Hypertension 1988; 12: 214-222
  • 25 Kaminsky LA, Imboden MT, Arena R. et al. Reference standards for cardiorespiratory fitness measured with cardiopulmonary exercise testing using cycle ergometry: Data from the Fitness Registry and the Importance of Exercise National Database (FRIEND) Registry. Mayo Clinic Proc 2017; 92: 228-233
  • 26 Peçanha T, Forjaz CLM, Low DA. Passive heating attenuates post-exercise cardiac autonomic recovery in healthy young males. Front Neurosci 2017; 11: 727
  • 27 Waldrop TG, Henderson MC, Iwamoto GA. et al. Regional blood flow responses to stimulation of the subthalamic locomotor region. Respir Physiol 1986; 64: 93-102
  • 28 Thornton JM, Aziz T, Schlugman D. et al. Electrical stimulation of the midbrain increases heart rate and arterial blood pressure in awake humans. J Physiol 2002; 539: 615-621
  • 29 Mitchell JH, Reeves DR, Rogers HB. et al. Autonomic blockade and cardiovascular responses to static exercise in partially curarized man. J Physiol 1989; 413: 433-445
  • 30 Victor RG, Pryor SL, Secher NH. et al. Effects of partial neuromuscular blockade on sympathetic nerve responses to static exercise in humans. Circ Res 1989; 65: 468-476
  • 31 Galbo H, Kjaer M, Secher NH. Cardiovascular, ventilatory and catecholamine responses to maximal dynamic exercise in partially curarized man. J Physiol 1987; 389: 557-568
  • 32 Nóbrega AC, Araújo CG. Heart rate transient at the onset of active and passive dynamic exercise. Med Sci Sports Exerc 1993; 25: 37-41
  • 33 Victor RG, Seals DR, Mark A. Differential control of heart rate and sympathetic nerve activity during dynamic exercise. Insight from intraneural recordings in humans. J Clin Invest 1987; 79: 508-516
  • 34 Fouladi B, Joshi H, Edgell H. Cardiovascular and autonomic responses to passive arm or leg movement in men and women. Eur J Appl Physiol 2019; 119: 551-559
  • 35 Shi P, Hu S, Yu H. The response of the autonomic nervous system to passive lower limb movement and gender differences. Med Biol Eng Comput 2016; 54: 1159-1167
  • 36 Goldberger JJ, Johnson NP, Subacius H. et al. Comparison of the physiologic and prognostic implications of the heart rate versus the RR interval. Heart Rhythm 2014; 11: 1925-1933
  • 37 O’Leary DS. Autonomic mechanisms of muscle metaboreflex control of heart rate. J Appl Physiol (1985) 1993; 74: 1748-1754
  • 38 Drew RC, Bell MP, White MJ. Modulation of spontaneous baroreflex control of heart rate and indexes of vagal tone by passive calf muscle stretch during graded metaboreflex activation in humans. J Appl Physiol (1985) 2008; 104: 716-723
  • 39 Vianna LC, Fisher JP. Reflex control of the cardiovascular system during exercise in disease. Current Opinion in Physiology 2019; 10: 110-117