Pharmacopsychiatry 2021; 54(02): 53-59
DOI: 10.1055/a-1298-4546

Treatment Goals for Patients with Schizophrenia — A Narrative Review of Physician and Patient Perspectives

Gerhard Gründer
1  Department of Molecular Neuroimaging,Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
Philipp Bauknecht
2  Dr. Carl GmbH, Stuttgart, Germany
Stefan Klingberg
3  Department of Psychiatry and Psychotherapy, University of Tuebingen, Germany
Karolina Leopold
4  Vivantes Klinikum Am Urban, Department of Psychiatry and Psychotherapy, Berlin, Germany
5  Carl Gustav Carus University Hospital, Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Germany
6  Alexianer Hospital, Aachen, Germany
7  Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany
8  JARA – Translational Brain Medicine, Jülich, Germany
Stefanie Schell
9  Harzklinikum Dorothea Christiane Erxleben, Klinikum Blankenburg, Akademisches Lehrkrankenhaus der Otto-von-Guericke-Universität Magdeburg, Germany
Katarina Stengler
10  Helios Parkklinikum Leipzig, Klinik für Psychiatrie, Psychotherapie und Psychosomatik, Akademisches Lehrkrankenhaus der Universität Leipzig, Germany
Stefan Leucht
11  Department of Psychiatry and Psychotherapy, School of Medicine, Technische Universität München, Germany
› Author Affiliations
Funding: This review was sponsored by Lundbeck GmbH, Hamburg, Germany and Otsuka Pharma GmbH, Frankfurt, Germany. All authors drafted and reviewed successive versions of the manuscript and had final control over the content. Lundbeck and Otsuka did not review or provide comments on the manuscript content. Medical writing and editorial support, including styling and editing for journal submission and performing the literature search, was provided by Dr. Carl GmbH, Stuttgart, Germany and was financially supported by Lundbeck and Otsuka.


Introduction There are many possible treatment goals for patients with schizophrenia. Two major perspectives on treatment goals are the patient’s and the physician’s perspective. Patient-centered treatment mandates that an individual patient’s treatment goals are taken into account when treatment is planned. In this narrative review, we address the commonalities and differences of the patient’s and physician’s perspectives.

Methods We searched for literature on treatment goals for patients with schizophrenia from the last 10 years.

Results Fifty-two relevant records were identified, 4 of which directly compare patient’s and physician’s perspectives. Two further articles used the same set of goals to ask patients or physicians for their assessment.

Discussion Agreement between patients and physicians regarding valuation of treatment goals was high. However, physicians tended to put more emphasis on the classical “textbook” goals of symptom resolution and functioning, while patients stressed well-being and quality of life more. Results on treatment goals from patients are difficult to generalize, since recruiting representative patient samples is challenging and patient subgroups may have differing priorities.

Supporting Information

Publication History

Received: 26 August 2020

Accepted: 21 October 2020

Publication Date:
08 December 2020 (online)

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