PDF herunterladen
Drug Res (Stuttg) 2021; 71(05): 233-242
DOI: 10.1055/a-1334-4101
Review

A Panoramic Review on Lepidium sativum L. Bioactives as Prospective Therapeutics

Asad Ahmad
1   Faculty of Pharmacy, Integral University, Dasauli, Kursi Road, Lucknow, Uttar Pradesh, India
,
Rabia Nabi
3   Department of Bioscience, Integral University, Dasauli, Kursi Road, Lucknow, Uttar Pradesh, India
,
Anuradha Mishra 
1   Faculty of Pharmacy, Integral University, Dasauli, Kursi Road, Lucknow, Uttar Pradesh, India
,
Iffat Zareen Ahmad
2   Department of Bioengineering, Integral University, Dasauli, Kursi Road, Lucknow, Uttar Pradesh, India
› Institutsangaben
› Weitere Informationen
Auch verfügbar auf
    Lizenzen und Reprints

Abstract

Background Lepidium sativum (L. sativum), an annual herb belonging to family Brassicaceae is commonly known as Garden cress of Egyptian origin but now a day’s cultivated worldwide. The plant material and its constituents are used in various traditional and folk medicines for the treatment of various liver diseases and other ailments.

Objective This review aims to gather comprehensive information on L. sativumʼs bioactive constituents, and itʼs antioxidant, hepato-protective and anticancer activity.

Method Systematic exploration for research evidences were carried out using well-structured and focused review question and presented data in the tabular form for readers’ convenience.

Results The comprehensive literature survey was conducted, and we found that specific studies on L. Sativum and its bioactive compounds had been carried out to date. We explored the unique and selective effect of L. Sativum and its bioactive constituents to combat oxidative stress and hepatic carcinoma.

Conclusion The present article appraised that L. sativum extract has a potential therapeutic effect against liver toxicity and hepato-carcinoma. [Graphical Abstract].

Key words

antioxidant - hepatoprotective - anticancer - toxicity - L. sativum

Supplementary Material



Publikationsverlauf

Eingereicht: 17. August 2020

Angenommen: 07. Dezember 2020

Artikel online veröffentlicht:
30. Dezember 2020

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References

  • 1 Sciarrillo R, Guarino M, Guarino C. Pharmacological activity of ethanolic extract Lepidium sativum Linn. seeds on thyroid hormones in male rats. IJPSR 2018; 9: 1699-1704
    PubMedGoogle Scholar
  • 2 Tiwari PN, Kulmi GS. Performance of Chandrasur (Lepidium sativum) under different levels of nitrogen and phosphorus. JMAPS 2004; 26: 479-481
    PubMedGoogle Scholar
  • 3 Anonymous The wealth of India: A dictionary of raw material and industrial products. Delhi: 2003: 276-277
    Google Scholar
  • 4 Sharma PC, Yelne MB, Dennis TJ. Database on medicinal plants used in Ayurveda, Government of India. 2000; 65-72
    PubMedGoogle Scholar
  • 5 Malar J, Vanmathi S, Chairman K. Phytochemical analysis of lepidium sativum using UV-VIS and GC-MS. Int. J Adv Res. 2018; 6: 813-825
    CrossrefPubMedGoogle Scholar
  • 6 Agarwal J, Verma DL. Antioxidative activity and flavonoid composition from Lepidium sativum . Nature and Science 2011; 9: 21-25
    PubMedGoogle Scholar
  • 7 Sat IG, Yildirim E, Turan M. et al. Antioxidant and nutritional characteristics of garden cress. Acta Sci Pol Hortorum Cultus 2013; 12: 173-179
    PubMedGoogle Scholar
  • 8 Malar J, Chairman K, Singh AR. et al. Antioxidative activity of different parts of the plant Lepidium sativum Linn. Biotechnol Rep 2014; 3: 95
    CrossrefPubMedGoogle Scholar
  • 9 Abuelgasim AI, Nuha HS, Mohammed AH. Hepatoprotective effect of Lepidium sativum against carbon tetrachloride induced damage in rats. Res J Anim Vet Sci 2008; 3: 20-23
    PubMedGoogle Scholar
  • 10 Shukla A, Bigoniya P. Hepatoprotective effect of Lepidium sativum Linn (Cruciferae) total alkaloid fraction against CCl4 induced hepatotoxicity on rats. Res J Pharmacog Phytochem 2013; 5: 94-99
    PubMedGoogle Scholar
  • 11 Bigoniya P, Shukla AK. Phytopharmacological screening of Lepidium sativum seeds total alkaloid: hepatoprotective, antidiabetic and in vitro antioxidant activity along with identification by LC/MS/MS. Pharma Nutrition 2014; 2: 90
    CrossrefPubMedGoogle Scholar
  • 12 Sakran M, Selim Y, Zidan N. A new isoflavonoid from seeds of Lepidium sativum L. and its protective effect on hepatotoxicity induced by paracetamol in male rats. Molecules 2014; 19: 15440-15451
    CrossrefPubMedGoogle Scholar
  • 13 Al-Asmari AK, Athar MT, Al-Shahrani HM. et al. Efficacy of Lepidium sativum against carbon tetra chloride induced hepatotoxicity and determination of its bioactive compounds by GC–MS. Toxicol Rep. 2015; 2: 1319-1326
    CrossrefPubMedGoogle Scholar
  • 14 Raish M, Ahmad A, Alkharfy KM. et al. Hepatoprotective activity of Lepidium sativum seeds against D-galactosamine/lipopolysaccharide induced hepatotoxicity in animal model. BMC Complem Altern M 2016; 16: 501
    CrossrefPubMedGoogle Scholar
  • 15 Kassie F, Rabot S, Uhl M. et al. Chemoprotective effect of garden cress (Lepidium sativium) and its constituents towards 2-amino-3-methyl-imidazo[4,5-f] quinolone (IQ)- induced genotoxic effects and colonic preneoplastic lesions. Carcinogenesis 2002; 23: 1155-1161
    CrossrefPubMedGoogle Scholar
  • 16 Al-Fatimi M, Friedrich U, Jenett-Siems K. Cytotoxicity of plants used in traditional medicine in Yemen. Fitoterapia 2005; 76: 355-358
    CrossrefPubMedGoogle Scholar
  • 17 Mahassni SH, Al-Reemi RM. Apoptosis and necrosis in the human breast cancer cell by an aqueous extract of garden cress (Lepidium sativum) seeds. Saudi J Biol Sci 2013; 20: 131-139
    CrossrefPubMedGoogle Scholar
  • 18 Mahassni SH, Al-Reemi RM. Cytotoxic effect of an aqueous extract of L. sativum seeds on human breast cancer cells. Indian J Tradit Know 2013; 12: 605-614
    PubMedGoogle Scholar
  • 19 Aslani E, Naghsh N, Ranjbar M. Cytotoxic effects of hydro-alcoholic extract of cress (Lepidium sativum) - made from different stages of the plant - on k562 Leukemia cell line. HMJ 2014; 18: 370-377
    PubMedGoogle Scholar
  • 20 Al-obaidi LAH. Study the anticancer effect of Lepidium sativum leaves extract on squamous cell carcinoma (CAL-27) cell lines. J Nat Sci Res 2014; 4: 48-52
    PubMedGoogle Scholar
  • 21 Indumathy R, Aruna A. Cytotoxic potential of various extracts of Lepidium sativum (Linn.) an in-vitro evaluation. Int J Pharmacol Pharm Sci 2015; 2: 1-5
    PubMedGoogle Scholar
  • 22 Ait-Yahia O, Bouzroura SA, Belkebir A. et al. Cytotoxic activity of flavonoid extracts from Lepidium sativum (Brassicaceae) seeds and leaves. IJPPR 2015; 7: 1231-1235
    PubMedGoogle Scholar
  • 23 Al-Sheddi ES, Farshori NN, Al-Oqail MM. et al. Protective effect of Lepidium sativum seed extract against hydrogen peroxide induced cytotoxicity and oxidative stress in human liver cells (HepG2). Pharm Biol. 2016; 54: 314-321
    CrossrefPubMedGoogle Scholar
  • 24 Maghrani M, Zeggwagh NA, Michel JB. et al. Antihypertensive effect of Lepidium sativum L. in spontaneously hypertensive rats. J Ethnopharmacol. 2005; 100: 193-197
    CrossrefPubMedGoogle Scholar
  • 25 Patel U, Kulkarni M, Undale V. et al. Evaluation of diuretic activity of aqueous and methanol extracts of Lepidium sativum garden cress (Cruciferae) in rats. TJPR 2009; 8: 215-219
    PubMedGoogle Scholar
  • 26 Al-yahya MA, Mossa JS, Ageel M. et al. Pharmacological and safety evaluation studies on Lepidium sativum L. seeds. Phytomedicine 1994; 1: 155-159
    CrossrefPubMedGoogle Scholar
  • 27 Ahsan SK, Tariq M, Ageel M. et al. Studies on some herbal drugs used in fracture healing. Int J Crude Drug Res 1989; 27: 235-239
    CrossrefPubMedGoogle Scholar
  • 28 Patole AP. Effect of mucilaginous seeds on in-vitro rate of starch hydrolysis and blood glucose levels of NIDDM subjects with special reference to garden cress seeds. JMAPS 1998; 20: 1005-1008
    PubMedGoogle Scholar
  • 29 Rehman N, Mehmood MH, Alkharfy KM. et al. Prokinetic and laxative activities of Lepidium sativum seed extract with species and tissue selective gut stimulatory actions. J Ethnopharmacol 2011; 134: 878-883
    CrossrefPubMedGoogle Scholar
  • 30 Manohar D, Shylaja H, Viswanatha GL. et al. Antidiarrheal activity of methanolic extracts of Lepidium sativum in rodent. J Nat Remidies 2009; 9: 197-201
    PubMedGoogle Scholar
  • 31 Paranjape AN, Mehta AA. A study on clinical efficacy of Lepidium sativum seeds in treatment of bronchial asthma. Iranian J Pharmacol Therap 2006; 5: 55-59
    PubMedGoogle Scholar
  • 32 Manohar D, Viswanatha GL, Nagesh S. et al. Ethnopharmacology of Lepidium Sativum Linn. (Brassicaceae): A review. Int J Phytother Res 2011; 2: 1-7
    PubMedGoogle Scholar
  • 33 Mali RG, Mahajan SG, Mehta AA. Studies on bronchodilatory effect of Lepidium sativum against allergen induced bronchospasm in guinea pigs. Pharmacogn Mag 2008; 4: 189-192
    PubMedGoogle Scholar
  • 34 Kar A, Panda S, Bharti S. Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice. J Ethnopharmacol 2002; 81: 281-285
    CrossrefPubMedGoogle Scholar
  • 35 Worldwide cancer data. https://www.wcrf.org/dietandcancer/cancer-trends/worldwide-cancer-data Accessed December 18 2018
  • 36 Garcia M, Jemal A, Ward EM. et al. Global Cancer Facts & Figures 2007. Atlanta, GA: American Cancer Society; 2007: 1-46
    Google Scholar
  • 37 El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007; 132: 2557-2576
    CrossrefPubMedGoogle Scholar
  • 38 Thun MJ, DeLancey JO, Center MM. et al. The global burden of cancer: priorities for prevention. Carcinogenesis 2010; 31: 100-110
    CrossrefPubMedGoogle Scholar
  • 39 Klaunig JE, Kamendulis LM. The role of oxidative stress in carcinogenesis. Annu Rev Pharmacol Toxicol 2004; 44: 239-267
    CrossrefPubMedGoogle Scholar
  • 40 Kawanishi S, Hiraku Y, Pinlaor S. et al. Oxidative stress and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis. Biol Chem 2006; 387: 365-372
    CrossrefPubMedGoogle Scholar
  • 41 Gius D, Spitz DR. Redox signaling in cancer biology. Antioxid Redox Signal 2006; 8: 1249-1252
    CrossrefPubMedGoogle Scholar
  • 42 Raval ND, Pandya TN. Pharmacognostic study of Lepidium Sativum Linn . AYU 2011; 32: 116-119
    CrossrefPubMedGoogle Scholar
  • 43 Nadkarni KM. Indian Materia Medica. Popular Publication; Mumbai: 1996: 596-599
    Google Scholar
  • 44 Kirthikar KR, Basu BD. Indian Medicinal Plants. Popular Publications; Dehradun: 1999: 1224-1227
    Google Scholar
  • 45 Billore KV, Yelne MB, Dennis TJ. et al. Database on medicinalplants used in ayurveda, Central Council for Research in Ayurveda and Siddha. New Delhi: 2005. 7. 1-52
    Google Scholar
  • 46 Ahamad R, Mujeeb M, Anwar F. et al. Phytochemical analysis and evaluation of anti-oxidant activity of methanolic extract of Lepidium sativum L. seeds. Pharm Lett. 2015; 7: 427-434
    PubMedGoogle Scholar
  • 47 Divekar VB, Kalaskar MG, Chougule PD. et al. Isolation and characterization of mucilage from Lepidium sativum Linn. seeds. IJPRD 2010; 2-1: 1-5
    PubMedGoogle Scholar
  • 48 Nayak PS, Upadhyay A, Dwivedi SK. et al. HPLC analysis of sinapic acid in Lepidium sativum . Electron. J. Environ. Agric. Food Chem 2012; 11: 156-162
    PubMedGoogle Scholar
  • 49 Mirza M, Navaei MN. Essential oil composition of Lepidium sativum L. IJMAP 2006; 21: 481-488
    PubMedGoogle Scholar
  • 50 Diwakar BT, Dutta PK, Lokesh BR. et al. Physicochemical properties garden cress (Lepidium sativum) seed oil. J Am Oil Chem Soc. 2010; 87: 539-548
    CrossrefPubMedGoogle Scholar
  • 51 Patel R, Kumar S, Jaiswal R. et al. Quantitative estimation of fixed oil obtained from seeds of Lepidium sativum Linn . Int J Chem Anal Sci 2010; 1: 6-9
    PubMedGoogle Scholar
  • 52 Irshad M, Zafaryab M, Singh M. et al. Comparative analysis of the antioxidant activity of Cassia fistula extracts. J. Med. Chem. 2012; 1: 1-6
    PubMedGoogle Scholar
  • 53 Aydemir T, Becerik S. Phenolic content and antioxidant activity of different extracts from Ocimum basilicum, Apium graveolens and Lepidium sativum seeds. J. Food Biochem 2010; 35: 62-79
    CrossrefPubMedGoogle Scholar
  • 54 Yadav YC, Srivastav DN, Seth AK. et al. In vivo antioxidant potential of Lepidium sativum L. seeds in albino rats using cisplatin induced nephrotoxicity. Int J Phytomed 2010; 2: 292-298
    PubMedGoogle Scholar
  • 55 Shirwaikar A, Patel B, Kamariya Y. et al. In vitro free radical scavenging potential of defatted ethanolic extract of the seeds of Lepidium sativum Linn. Chin J Nat Med 2011; 9: 0435-0440
    PubMedGoogle Scholar
  • 56 Zia-Ul-Haq M, Ahmad S, Calani L. et al. Compositional study and antioxidant potential of Ipomoea hederacea Jacq. and Lepidium sativum L. seeds. Molecules 2012; 17: 10306-10321
    CrossrefPubMedGoogle Scholar
  • 57 Chatoui K, Talbaoui A, Aneb M. et al. Phytochemical screening, antioxidant and antibacterial activity of Lepidium sativum seeds from Morocco. J Mater Environ Sci 2016; 7: 2938-2946
    Google Scholar
  • 58 Agarwal J, Verma DL. Antioxidant activity- guided fractionation of aqueous extracts from Lepidium sativum and identification of active flavonol glycosides. Academia Arena 2011; 3: 14-18
    PubMedGoogle Scholar
  • 59 Bhasin P, Bansal D, Yadav O. et al. In vitro antioxidant activity and phytochemical analysis of seed extracts of Lepidium sativum- a medicinal herb. J Biosci Technol 2011; 2: 410-415
    PubMedGoogle Scholar
  • 60 Yadav YC, Srivastava DN, Saini V. et al. In vitro antioxidant activities of ethanolic extract of Lepidium sativum L. seeds. Pharma Science Moniter An Int J Pharm Sci 2011; 2: 244-253
    PubMedGoogle Scholar
  • 61 Indumathy R, Aruna A. Free radical scavenging activities, total phenolic and flavonoid content of L. sativum L. Int J Pharm pharm Sci 2013; 25: 634-637
    PubMedGoogle Scholar
  • 62 Althnaian T. Influence of dietary supplementation of garden cress (Lepidium sativum L.) on liver histopathology and serum biochemistry in rats fed high cholesterol diet. J Adv Vet Anim Res. 2014; 1: 216-223
    CrossrefPubMedGoogle Scholar
  • 63 Al-hamedan WA. Protective effect of Lepidium sativum L. seeds powder and extract on hypercholesterolemic rats. J Am Sci 2010; 6: 873-879
    PubMedGoogle Scholar
  • 64 Behera B, Dash J, Pradhan D. et al. Apoptosis and necrosis of human breast cancer cells by an aqueous extract of Euphorbia hirta leaves. J Young Pharm 2016; 8: 186-193
    CrossrefPubMedGoogle Scholar
  • 65 Ageel AM, Tariq M, Mossa JS. et al. Plants used in saudi folk medicine. Experimental report submitted to the King Abdulaziz city for science and technology, King Saud University press; Riyadh, Saudi Arabia: 1987. 6. 294
    Google Scholar
  • 66 Adam SEI. Effect of various level of dietary Lepidium sativum L. seeds in rat. AJCM 1999; 27: 397-405
    PubMedGoogle Scholar
  • 67 Datta PK, Diwakar BT, Viswanatha S. et al. Safety evaluation studies on garden cress (Lepidium sativum L.) seeds in wistar rats. Int J Appl Res Nat Prod 2011; 4: 37-43
    PubMedGoogle Scholar
  • 68 Naik A, Meda V, Lele SS. Application of EPR spectroscopy and DSC for oxidative stability studies of Nigella sativa and Lepidium sativum seed oil. J Am Oil Chem Soc 2014; 91: 935-941
    CrossrefPubMedGoogle Scholar
  • 69 Qusti S, El-Rabey HA, Balashram SA. The hypoglycemic and antioxidant activity of cress seed and cinnamon on streptozotocin induced diabetes in male rats. J Evid Based Complementary Altern Med 2016; 2016: 1-15
    CrossrefPubMedGoogle Scholar
  • 70 Desai SS, Walvekar MV, Shaikh NH. Cytoprotective effects of Lepidium sativum seed extract on liver and pancreas of HFD/STZ induced type 2 diabetic mice. IJPPR 2017; 9: 502-505
    PubMedGoogle Scholar