Synlett
DOI: 10.1055/a-1493-9489
synpacts

Enantioselective Functionalization of Prochiral Cyclobutanones and Cyclobutenones

Meng Wang
,
Changxu Zhong
,
Ping Lu
This work was supported by the National Natural Science Foundation of China (Grant Numbers 21772024 and 21921003).


Abstract

Enantioselective synthesis of cyclobutane derivatives is still a challenging topic in asymmetric synthesis. [2+2] Cycloaddition and skeleton rearrangement are two primary strategies to this end. Recently, functionalization of cyclobutanones and cyclobutenones, which are readily available via [2+2] cycloadditions as prochiral substrates, has emerged as a powerful tool to access versatile four-membered ring compounds. Herein, we summarize some recent advances in these areas from our and other groups.

1 Introduction

2 Enantioselective Functionalization of Cyclobutanones

2.1 Chiral Lithium Amide Approach

2.2 Enamine Approach

3 Enantioselective Functionalization of Cyclobutenones

4 Conclusion



Publication History

Received: 01 April 2021

Accepted after revision: 28 April 2021

Publication Date:
28 April 2021 (online)

© 2021. Thieme. All rights reserved

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
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