Die autoimmune Hepatitis gehört zu den seltenen immunologisch vermittelten Lebererkrankungen
mit chronisch-fluktuierendem Verlauf. Unbehandelt führt sie in den meisten Fällen
zur Leberzirrhose mit den damit verbundenen Komplikationen. Dieser Beitrag bietet
einen Überblick über klinisch relevante Aspekte bei der Betreuung betroffener Patient/-innen.
Abstract
Autoimmune hepatitis is a rare but chronic autoimmune-mediated liver disease. Key
features are elevated transaminases, hypergammaglobulinemia, presence of specific
autoantibodies and typical histological features. Diagnostic scores are helpful in
establishing the diagnosis. Immunosuppressive therapy should be initiated in every
patient with inflammatory activity. First-line therapy includes steroids and azathioprine
and results in biochemical and histological remission in the majority of patients.
In most cases, lifelong therapy is required. Every patient should receive regular
follow-up surveillance including biochemical parameters as well as sonography and
elastography.
Schlüsselwörter
autoimmune Hepatitis - autoimmune Lebererkrankungen - Hypergammaglobulinämie - Transaminasenerhöhung
- Azathioprin
Key words
autoimmune hepatitis - autoimmune liver diseases - hypergammaglobulinemia - elevated
transaminases - azathioprine
