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Drug Res (Stuttg) 2021; 71(09): 504-511
DOI: 10.1055/a-1533-2900
Original Article

Study of Reproductive Toxicity of the Liposomal Photosensitizer Lipophthalocyan

Olga Konyaeva
1   N.N. National Medical Research Center of Oncology, Moscow, Russia
,
Nataliya Kulbachevskaya
1   N.N. National Medical Research Center of Oncology, Moscow, Russia
,
Vera Chaley
1   N.N. National Medical Research Center of Oncology, Moscow, Russia
,
Nadezhda Ermakova
1   N.N. National Medical Research Center of Oncology, Moscow, Russia
,
Pavel Varaksa
1   N.N. National Medical Research Center of Oncology, Moscow, Russia
,
Anna Lantsova
1   N.N. National Medical Research Center of Oncology, Moscow, Russia
,
Lyudmila Nikolaeva
1   N.N. National Medical Research Center of Oncology, Moscow, Russia
2   Sechenov University, Moscow, Russia
,
Olga Orlova
1   N.N. National Medical Research Center of Oncology, Moscow, Russia
,
Yuliya Rodionova
1   N.N. National Medical Research Center of Oncology, Moscow, Russia
,
Natalia Bunyatyan
2   Sechenov University, Moscow, Russia
3   Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Health of Russia, Moscow, Russia
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Abstract

Objective Study of embryotoxicity, teratogenicity and reproductive toxicity of the new drug Lipophtalocyan in rats.

Material and Methods Studies were conducted on 210 non-inbred female rats and 105 non-inbred male rats. The drug was administered daily via i. v. injection for 48 days (males) and for 15 days (females) in 2 total doses corresponding to the therapeutic dose (TD) for mice when converted to rats and 10 TD.

Results and Conclusion When mating with intact female rats, no changes in sexual behavior were observed, but the index of the ability to fertilize and conceive decreased when compared to the values of the control group by 35–40% (TD index=60%) and by 75–80% (10 TD index=20%). The index of the ability to fertilize and conceive differed from the values of the control group by 90% (TD index=5%) and by 15% (10 TD index=80%). There were no differences in the indicator of embryotoxicity and teratogenicity in intact and drug-treated female rats, compared with the control group. Lipophtalocyan has a negative effect on the male and female reproductive function in rats and has an embryotoxic effect according to the index of the ability to fertilize and conceive, as well as the indices of preimplantation and post-implantation fetal death. The drug does not have a teratogenic effect, neither it affects the physical development of offspring or the rate of maturation of sensory-motor reflexes during feeding.

Key words

embryotoxicity - teratogenicity - preimplantation mortality - post-implantation mortality


Publikationsverlauf

Eingereicht: 25. März 2021

Angenommen: 21. Juni 2021

Artikel online veröffentlicht:
29. Juli 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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