Modeling the Effects of Intravasal Administration of AstraZeneca ChAdOx1 nCoV-19 Vaccine on Human Platelets

Thromb Haemost 2021; 121(12): 1681-1683
DOI: 10.1055/a-1579-5308

Letter to the Editor

Authors

Pernille Just Vinholt

¹Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark

²Department of Clinical Research, University of Southern Denmark, Denmark
Henrik Frederiksen

²Department of Clinical Research, University of Southern Denmark, Denmark

³Department of Haematology, Odense University Hospital, Odense, Denmark
Christian Nielsen

⁴Department of Clinical Immunology, Odense University Hospital, Odense, Denmark

References
1 Schultz NH, Sørvoll IH, Michelsen AE. et al. Thrombosis and thrombocytopenia after ChAdOx1 nCoV-19 vaccination. N Engl J Med 2021; 384 (22) 2124-2130
2 Greinacher A, Thiele T, Warkentin TE, Weisser K, Kyrle PA, Eichinger S. Thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination. N Engl J Med 2021; 384 (22) 2092-2101
3 Stone D, Liu Y, Shayakhmetov D, Li ZY, Ni S, Lieber A. Adenovirus-platelet interaction in blood causes virus sequestration to the reticuloendothelial system of the liver. J Virol 2007; 81 (09) 4866-4871
4 Nicolai L, Leunig A, Pekayvaz K. et al. Thrombocytopenia and splenic platelet directed immune responses after intravenous ChAdOx1 nCov-19 administration. bioRxiv 2021;
5 Just Vinholt P, Højrup Knudsen G, Sperling S, Frederiksen H, Nielsen C. Platelet function tests predict bleeding in patients with acute myeloid leukemia and thrombocytopenia. Am J Hematol 2019; 94 (08) 891-901
6 Arnold DM, Curtis BR, Bakchoul T. Platelet Immunology Scientific Subcommittee of the International Society on Thrombosis and Hemostasis. Recommendations for standardization of laboratory testing for drug-induced immune thrombocytopenia: communication from the SSC of the ISTH. J Thromb Haemost 2015; 13 (04) 676-678
7 Vinholt PJ, Alnor A, Nybo M, Hvas AM. Prediction of bleeding and prophylactic platelet transfusions in cancer patients with thrombocytopenia. Platelets 2016; 27 (06) 547-554