Expression of Prostate Specific Membrane Antigen (PSMA) in Breast Cancer

Clara Unger; Peter Bronsert; Kerstin Michalski; Anna Bicker; Ingolf Juhasz-Böss

doi:10.1055/a-1638-9429

Geburtshilfe und Frauenheilkunde, Table of Contents

CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2022; 82(01): 50-58
DOI: 10.1055/a-1638-9429

GebFra Science

Review/Übersicht

Expression of Prostate Specific Membrane Antigen (PSMA) in Breast Cancer

Article in several languages: English | deutsch

Authors

Clara Unger

¹Klinik für Frauenheilkunde, Universitätsklinikum Freiburg, Freiburg, Germany
Peter Bronsert

²Institut für Klinische Pathologie, Universitätsklinikum Freiburg, Freiburg, Germany
Kerstin Michalski

³Klinik für Nuklearmedizin, Universitätsklinikum Freiburg, Freiburg, Germany
Anna Bicker

⁴Klinik für Gynäkologie und Geburtshilfe in den St. Vincentius Kliniken, Karslruhe, Germany
Ingolf Juhasz-Böss

¹Klinik für Frauenheilkunde, Universitätsklinikum Freiburg, Freiburg, Germany

Abstract

Background Prostate specific membrane antigen (PSMA) is a promising protein for breast cancer patients. It has not only been detected in prostate cancer but is also expressed by tumor cells and the endothelial cells of tumor vessels in breast cancer patients. PSMA plays a role in tumor progression and tumor angiogenesis. For this reason, a number of diagnostic and therapeutic methods to target PSMA have been developed.

Method This paper provides a general structured overview of PSMA and its oncogenic potential, with a special focus on its role in breast cancer. This narrative review is based on a selective literature search carried out in PubMed and the library of Freiburg University Clinical Center. The following key words were used for the search: “PSMA”, “PSMA and breast cancer”, “PSMA PET/CT”, “PSMA tumor progression”. Relevant articles were explicitly read through, processed, and summarized.

Conclusion PSMA could be a new diagnostic and therapeutic alternative, particularly for triple-negative breast cancer. It appears to be a potential predictive and prognostic marker.

Key words

PSMA - breast cancer - radioligand therapy - immunohistochemistry - PET/CT

Full Text

References

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