Modulation of von Willebrand Factor Function by Domain C4 Mutations

• References

• 1 Zwaginga JJ, Sakariassen KS, Nash G. et al; Biorheology Subcommittee of the SSC of the Isth. Flow-based assays for global assessment of hemostasis. Part 2: current methods and considerations for the future. J Thromb Haemost 2006; 4 (12) 2716-2717
• 2 Schneppenheim R, Hellermann N, Brehm MA. et al. The von Willebrand factor Tyr2561 allele is a gain-of-function variant and a risk factor for early myocardial infarction. Blood 2019; 133 (04) 356-365
• 3 Huck V, Chen PC, Xu ER. et al. Gain-of-function variant p.Pro2555Arg of von Willebrand factor increases aggregate size through altering stem dynamics. Thromb Haemost 2021;