Veranlagung und Lebensstil – die Komplexität des Diabetes mellitus – Langerhans-Medaille 2021 – eine Kurzübersicht über den Preisträger Martin Hrabě de Angelis

• Literatur

• 1 Hrabě de Angelis M, Nicholson G, Selloum M. et al. Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics. Nat Genet 2015; 47: 969-978
• 2 Rozman J, Rathkolb B, Oestereicher M.A. et al. Identification of genetic elements in metabolism by high-throughput mouse phenotyping. Nat Commun 2018; 9: 288
• 3 Vogel H, Kamitz A, Hallahan N. et al. A collective diabetes cross in combination with a computational framework to dissect the genetics of human obesity and Type 2 diabetes. Human Molecular Genetics 2018; 27 (17) 3099-3112
• 4 Seitz S, Kwon Y, Hartleben G. et al. Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity. Nat Metab 2019; 1: 1009-1026
• 5 Wagner R, Heni M, Tabák AG. et al. Pathophysiology-based subphenotyping of individuals at elevated risk for type 2 diabetes. Nat Med 2021; 27: 49-57
• 6 Zaharia OP, Strassburger K, Strom A. et al. Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes: a 5-year follow-up study. Lancet Diabetes Endocrinol 2019; 7 (09) 684-694
• 7 Fritsche A, Wagner R, Heni M. et al. Different Effects of Lifestyle Intervention in High- and Low-Risk Prediabetes. Diabetes 2021;
• 8 Zaharia OP, Strassburger K, Knebel B. et al. Role of Patatin-Like Phospholipase Domain-Containing 3 Gene for Hepatic Lipid Content and Insulin Resistance in Diabetes. Diabetes Care 2020; 43 (09) 2161-2168
• 9 Huypens P, Sass S, Wu M. et al. Epigenetic germline inheritance of diet-induced obesity and insulin resistance. Nat Genet 2016; 48: 497-499
• 10 Kaspar D, Hastreiter S, Irmler M. et al. Nutrition and its role in epigenetic inheritance of obesity and diabetes across generations. Mamm Genome 2020; 31: 119-133
• 11 Lassi M, Tomar A, Comas-Armangué G. et al. Disruption of paternal circadian rhythm affects metabolic health in male offspring via nongerm cell factors. Sci Adv 2021; 7 (22) eabg6424
• 12 Dedié A, Bleimehl T, Täger J. et al. DZDconnect: mit vernetzten Daten gegen Diabetes. Diabetologie 2021;